larger food substances are allowed to enter the blood stream causing antibody produc- tion and hyperallergenicity. It is “implicated in the pathogenesis of several acute and chronic pediatric disease entities” including inflammatory bowel disease, type I diabe- tes, allergies, asthma, and autism. Causes of Leaky Gut Syndrome are: (1) Low levels of sulfate from heredity; (2) Toxins such as heavy metals, pesticides, and toxins from pathogens; (3) Dysfunctional DPPIV causing incomplete digestion of gluten and casein (a vicious cycle); (4) Other food sensitivi- ties (IgG based); (5) Bacterial, fungal, viral, parasitic infection (gastroenteritis); (6) Zinc deficiency; and (7) Medications such as antibiotics, non-steroidal anti-inflammatory drugs like Motrin, Aleve and Advil. Medi- cal conditions associated with Leaky Gut Syndrome are: autoimmune disease, Celiac disease, Crohn’s disease, Multiple Chemical Sensitivities, hives, acnes, allergies, arthri- tis, autism, intestinal infections, pancreatic insufficiency, Ulcerative Colitis, Giardia- sis, Chronic Fatigue Syndrome, Eczema, Psoriasis, liver dysfunction, Irritable Bowel Syndrome, food allergies/sensitivities.
Gastrointestinal Immune System – the “soldiers”
I name the gastrointestinal immune system, the “soldiers”. The major function of the gut’s immune system is to protect the host from pathogens or invaders. T lym- phocytes (or T cells) and B cells are located in lymphoid organs (liver and spleen) and peripheral lymph nodes. T cells are either Th1 or Th2 cells. Th1 cells are responsible for cellular immunity and direct T cells and macrophages to fight viruses, parasites and yeast. Th2 cells, on the other hand, are responsible for humoral immunity and cre- ate antibodies to neutralize foreign invaders outside the cell. B cells produce antibodies: IgE (the Air Force), the IgG (the Reserves), IgM (the Marines), and IgA (the Navy). In a normal healthy immune system, there is a balance between Th1 and Th2 activity; meaning, Th1 can switch to Th2 and vice versa. Inability to switch to TH1 leads to chronic infection with yeast, parasites and viruses causing Chronic Fatigue Syndrome. On the contrary, overactive Th2 re- sponse can lead to autoimmunity, allergies,
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