to protect the heart, prevent osteoporosis and cancer; Biotin which is involved in cellular processes that basically convert your food into energy; and Vitamin B12 and folate (Vitamin B9) which are very important in methylation (process by which a gene’s behavior is altered) and detoxification (physiologic removal of toxins from the body). Only certain bacteria that live in the gut of animals are able to produce Vitamin B12 that is useful to humans. Therefore, the plant-based form of vitamin B12 is insufficient supplementation for humans especially those who are vegan or vegetarian. Since vitamin B12 helps absorb folic acid, people who avoid eating meat are likely to be deficient in B12 and folic acid as well. The enzyme responsible for activating folic acid to 5-methyltetrahydrofolate is known as MTHFR (methylenetetrahydrofolate reductase). With the popularity of MTHFR testing in young women, I am finding that mu- tations are not uncommon in this population. MTHFR mutations are associated with Spina Bifida and neural tube defects; and MTHFR deficiency causes accumulation of homocysteine in the body called Homocysteinemia which is associated with heart disease and stroke. Therefore, a word of advice to young women who are vegan or
vegetarian - please have adequate supplementation of activated B12 or Methylcobalamin and activated folic acid such as methyltetrahy- drofolate and folinic acid. You can find supplements that have these two B vitamins and Vitamin B6; and in fact, there is a prescription medication that has all of them. All three B vitamins are necessary for proper methylation and to decrease homocysteine. Emerging studies have shown that our gut bacteria have more genes than humans themselves and that the diversity of bacteria you have in your gut may dictate your health. In addition, “crosstalk” be- tween gut microbiome and immunity and metabolic processes may be disrupted by modern lifestyle, diet, overuse of antibiotics causing inflammation and chronic illness. Let us go back to our “kingdom” analogy. The ruler of the kingdom is the beneficial bacteria, and the subordinates are the pathogenic bacteria and yeast. What happens when the king is overthrown by the subordinates? You develop Gut Dysbiosis; and in allopathic medicine language it is called Small Intestinal Bacterial Overgrowth or SIBO. This is described as an overgrowth of harmful bacteria and yeast and deficiency of beneficial bacteria. Causes of bacterial overgrowth are (1) Antibiotics, especially broad-spectrum; (2) Acid reducers like H2 blockers (Tagamet, Zantac, Pepcid, etc.)
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