| DERMATOLOGY | PEER-REVIEW Key points Polynucleotides (PN)
are natural DNA fractions that perform a trophic action on cells and are widely used for skin biorevitalisation through intradermal injections
They are a valid option for treating wrinkles and counteracting skin ageing
the exact mechanism by which Minoxidil induces hair growth is still unknown. Some authors suggest
that
Minoxidil improves the release of adenosine, which in turn acts on specific adenosine receptors of hair follicles releasing vascular endothelial growth factor27
. This mechanism of action is particularly interesting as,
since they are DNA fractions, PN gradually release adenosine during catabolism. Thus, the stimulation of dermal papilla cells could be the result of the action performed by adenosinic nucleotides on A2 purinergic receptors. These considerations tend to support the effectiveness
of PN the authors observed in the clinical assessment based on PN administration. These proved to be molecules of the very first choice when significant stimulation of the cells of the dermal papillae is required in order to support the trophometabolic activity, thus causing a substantial improvement in cases of female hormonal hair loss.
Conclusions The results of this clinical evaluation confirm that trophic stimulation performed by PN in the scalp promoted the growth of hair in cases of female hormonal hair loss. This clinical investigation also confirmed the safety of
the medical device and its good tolerability. According to the protocol presented in the study,
polynucleotides for scalp injections are an effective, safe, and non invasive procedure for patients. Other surgeons can easily repeat the treatment. Despite the clear limits of the authors’ study owing to the reduced size of the sample, as far as they are aware, these are the first data available on the efficacy of polynucleotides evaluated on the basis of different objective criteria (trichogram, hair count, hair density, pull test). They show that the treatment with polynucleotides is effective in improving hair regeneration and in counteracting the female hormonal hair loss. In the light of these results it could be interesting to evaluate the action of polynucleotides on hair regeneration following different pattern of hair loss, such as alopecia areata and male androgenetic alopecia. Polynucleotides could be also useful as adjuvant post
surgery treatment after hair transplant surgery. All the above mentioned clinical conditions could be the objects of further interesting studies and trials.
Declaration of interest None of the authors has conflict
of interest to disclose. The product was kindly supplied free of charge (Plinest®fast, Mastelli srl, Italy)
Figures 1–4 Data © Dr Torello Lotti, redrawn by Prime
Journal Figures 5-7 © Dr Torello Lotti Table 1 Illustration © Kevin February
Polynucleotides (PN) stimulate cell growth and regeneration in different cell lineage and in hair follicles, through the adenosine receptors (A2 purinergic receptors)
The study showed
that Polynucleotides for intradermal injection in the scalp promote hair growth in female hormonal hair loss.
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