| DERMATOLOGY | PEER-REVIEW
Figure 3 Anagen/telogen ratio 3.5 3
2.5 2
1.5 1
0.5 0
T0 T30 T60 T120
Anagen/Telogen ratio from the Trichogram evaluations at baseline (T0) and after 1 month (T30), 2 months (T60), 4 months (T120)
Figure 4 Wash test
100 90 80 70 60 50 40 30 20 10 0
T0 T30 T60 T120
Result of wash test: fallen hair count (wash-test applied by the patient after hair wash) at baseline (T0) and after 1 month (T30), 2 months (T60), 4 months (T120)
The examinations included clinical observation, a number of different instrumental tests, and the patients’ own subjective considerations.
With regard to their case histories, none of the patients
reported any current or earlier systemic diseases able to accentuate their hair loss (e.g. low serum iron levels, febrile diseases, endocrine diseases, liver diseases) and none reported having followed slimming diets. No current or recent conditions of psychophysical stress were reported. None of the patients examined were receiving pharmacological treatment or taking contraceptive pills. Two patients reported that they were mild smokers, with a daily average of 6–8 cigarettes. All patients appeared to be in good conditions of
health, with the presence of progressive thinning of the hair adnexa on their scalps. All patients provided informed consent.
Methods PN were administered using pre-filled syringes (Plinest®
Fast 7.5 mg/ml; Mastelli Ltd, Sanremo, Italy) by means of intradermal infiltration, using the serial puncture technique and injecting 0.2 ml of product for each puncture at a distance of 3–5 cm from one another. The product was distributed uniformly throughout the area affected by alopecia by administering one whole syringe (1.3 ml) per patient at each infiltration session. The treatment protocol called for one infiltration
session per week for the first 4 weeks, followed by one every 2 weeks for 3 months. Accordingly, the treatment lasted for an overall period of four months, with a total of 10 infiltration sessions. The patients were advised to wash their hair three
times per week using a mild shampoo. Clinical assessments were carried out at the start of the
treatment (T0), after 1 month (T30), after 2 months (T60), and at the end of the 4-month study period (T120).
Figure 5 Videodermoscopy: average number of hairs in a standard surface pre- and post-treatment (T0 vs T120). (A) T0, 105 hairs/cm2
; (B) T120, 118 hairs/cm2
prime-journal.com | July/August 2014
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Anagen/telogen ratio
Fallen hair count
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