PEER-REVIEW | DERMATOLOGY | Figure 7 Clinical results
before and after 4 months. Patient. 1 (A) before and (B) after treatment. Patient 2 (C) before and (D) 4 months after treatment
was conducted with the same protocol of treatment
used in above trial. It showed a positive efficacy that was evaluated by pre and post-treatment digital pictures and by physician assessments; in 72% of the patients the physician noted a clinical improvement of female androgenetic alopecia with no side effects and high patient compliance.
According to the protocol
presented in the study, polynucleotides for scalp injections are an effective, safe, and non invasive procedure for patients.
For these reasons, the authors also started to use them
in trichology in order to investigate the possibility of stimulating trophism of hair follicles in poor condition. It is well known that fibroblast growth factor (FGF) is
extensively involved in the development of hair follicles, and is considered an important mediator in their metabolism and differentiation. Immunohistochemical studies found A2 receptors (adenosine receptors) in the dermal papilla cells of hair follicles27
. It has been shown12
that incubation of the hair adnexa with 25 m of adenosine significantly increased the concentration of intracellular AmpC in the dermal papillae. To be precise, the production of AmpC appeared to depend specifically on the interaction of adenosine with A2 receptors28–30
. It would
therefore seem reasonable to assume that AmpC or similar substances are crucial for the positive control of FGF-7, which regulates the development of the hair follicles. Specifically, studies were conducted on cultures of hair
follicles in the anagen phase incubated with FGF-712
. A more significant growth in
length was observed by comparison with control cultures after only 6 days, as well as a
longer duration of the anagen phase in the context of increased proliferation and differentiation of the follicle cells12
. In the treatment of androgenic
alopecia Minoxidil is the only approved topical treatment, but
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