Livestock Management • At score 3 there is drooling,
RANCHING
Extended-Release Injectable Parasiticide 5% Sterile Solution NADA 141-327, Approved by FDA for subcutaneous injection For the Treatment and Control of Internal and External Parasites of Cattle on Pasture with Persistent Effectiveness
CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
INDICATIONS FOR USE LONGRANGE, when administered at the recommended dose volume of 1 mL per 110 lb (50 kg) body weight, is effective in the treatment and control of 20 species and stages of internal and external parasites of cattle:
Gastrointestinal Roundworms Cooperia oncophora – Adults and L4
Cooperia punctata – Adults and L4 Cooperia surnabada – Adults and L4 Haemonchus placei – Adults
Oesophagostomum radiatum – Adults Ostertagia lyrata – Adults
Ostertagia ostertagi – Adults, L4 and inhibited L4
,
Trichostrongylus axei – Adults and L4 Trichostrongylus colubriformis – Adults
Parasites
Gastrointestinal Roundworms Cooperia oncophora Cooperia punctata Haemonchus placei
Oesophagostomum radiatum Ostertagia lyrata
Ostertagia ostertagi Trichostrongylus axei
Lungworms Dictyocaulus viviparus
Durations of Persistent Effectiveness
100 days 100 days 120 days 120 days 120 days 120 days 100 days
150 days
DOSAGE AND ADMINISTRATION LONGRANGE™ (eprinomectin) should be given only by subcutaneous injection in front of the shoulder at the recommended dosage level of 1 mg eprinomectin per kg body weight (1 mL per 110 lb body weight).
WARNINGS AND PRECAUTIONS Withdrawal Periods and Residue Warnings
Animals intended for human consumption must not be slaughtered within 48 days of the last treatment. This drug product is not approved for use in female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. A withdrawal period has not been established for pre-ruminating calves. Do not use in calves to be processed for veal.
Animal Safety Warnings and Precautions The product is likely to cause tissue damage at the site of injection, including possible granulomas and necrosis. These reactions have disappeared without treatment. Local tissue reaction may result in trim loss of edible tissue at slaughter. Observe cattle for injection site reactions. If injection site reactions are suspected, consult your veterinarian. This product is not for intravenous or intramuscular use. Protect product from light. LONGRANGE™ (eprinomectin) has been developed specifically for use in cattle only. This product should not be used in other animal species.
When to Treat Cattle with Grubs LONGRANGE effectively controls all stages of cattle grubs. However, proper timing of treatment is important. For the most effective results, cattle should be treated as soon as possible after the end of the heel fly (warble fly) season.
Environmental Hazards Not for use in cattle managed in feedlots or under intensive rotational grazing because the environmental impact has not been evaluated for these scenarios.
Other Warnings: Underdosing and/or subtherapeutic concentrations of extended-release anthelmintic products may encourage the development of parasite resistance. It is recommended that parasite resistance be monitored following the use of any anthelmintic with the use of a fecal egg count reduction test program.
TARGET ANIMAL SAFETY Clinical studies have demonstrated the wide margin of safety of LONGRANGE™ (eprinomectin). Overdosing at 3 to 5 times the recommended dose resulted in a statistically significant reduction in average weight gain when compared to the group tested at label dose. Treatment-related lesions observed in most cattle administered the product included swelling, hyperemia, or necrosis in the subcutaneous tissue of the skin. The administration of LONGRANGE at 3 times the recommended therapeutic dose had no adverse reproductive effects on beef cows at all stages of breeding or pregnancy or on their calves. Not for use in bulls, as reproductive safety testing has not been conducted in males intended for breeding or actively breeding. Not for use in calves less than 3 months of age because safety testing has not been conducted in calves less than 3 months of age.
STORAGE Store at 77° F (25° C) with excursions between 59° and 86° F (15° and 30° C). Protect from light.
Made in Canada. Manufactured for Merial Limited, Duluth, GA, USA. ®The Cattle Head Logo is a registered trademark, and ™LONGRANGE is a trademark, of Merial. ©2012 Merial. All rights reserved. 1050-2889-02, Rev. 05/2012
Lungworms Dictyocaulus viviparus – Adults Grubs Hypoderma bovis Mites Sarcoptes scabiei var. bovis
open-mouth panting (120 to 160 breaths per minute), the neck is extended and head held upward. • At panting score 4 the tongue
is fully extended out of the mouth for long periods, with excessive drooling, the head is still extended upward, with breaths more than 160 per minute. You can’t even count the respiration rate when it’s this rapid. “The critical level is score 4.5
because by then the head is low and the animal is breathing from the fl ank and may stop drooling because it’s so dehydrated. At this point, risk of death is high. When they start going into heat stroke, they stop sweating because they are dehydrated and everything is shutting down,” Spiers explains. “We published a paper on sweat-
ing rates and how it differs over different parts of the body — how much they sweat. The shoulder area has the highest amount of sweating. Rump and legs are less. If you use fans, aim them at the shoulder,” says Spiers. “When we did studies on heat
stress and put cattle in environ- mental chambers at the University of Missouri, we found sweating rate went up during the fi rst few days, and then dropped. Their internal body temperatures were still high, but they sweated less. The body chose not to keep the sweating rate high. It was more important to con- serve water (to prevent dehydration) than to maintain constant body temperature,” he says.
Enough water to allow cattle to eat “You must look at different
things when assessing the health of these animals. We check body temperature, but water intake is
LONGRANGE-PI_InBrief_THE
CATTLEMAN.indd 1 12/6/12 2:17 PM 60 The Cattleman August 2013
regulated separately by the body and seems to be more important. Animals always need adequate wa- ter. They will actually reduce their water loss after they’ve adapted to heat, and still keep their body temperature high.” This shows the importance of water, because once they become too dehydrated they will die. “We did a study looking at de-
hydration, trying to come up with indicators of dehydration that a cat- tle producer could use. The major indicator of dehydration we found was decreased feed intake. They just stop eating.” When cattle can’t mix enough fl uid with the feed, they can’t eat. They can’t produce saliva if the body is short on fl uid. “If you see an animal that’s not
eating well, it might not be getting enough water. We did this study using environmental chambers and found that body temperature didn’t actually go up that much as heat in the chamber rose, but feed intake plummeted when they didn’t have access to water,” says Spiers. “We also saw that when they were de- hydrated their sweat rates dropped. They didn’t have enough moisture to sweat.” Various research groups have
tried to come up with better indices of heat stress in feedlot cattle. “John Gaughan published a paper in 2007 showing that you can use ambi- ent values to determine how hot the animals would be. He worked with several thousand cattle — Bos taurus as well as Bos indicus. He found he could use black globe tem- perature (which measures actual temperature of an object in the sun- shine — which is generally hotter than air temperature), relative hu- midity and wind speed to come up with a heat load index (HLI) to use as a management tool,” says Spiers.
thecattlemanmagazine.com
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108 |
Page 109 |
Page 110 |
Page 111 |
Page 112 |
Page 113 |
Page 114 |
Page 115 |
Page 116 |
Page 117 |
Page 118