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International Journal of Aesthetic and Anti-Ageing Medicine Informa Healthcare, 119 Farringdon Road, London, EC1R 3DA, UK

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antibiotics, the incidence of antibiotic resistance and the availability of more effective, well-tolerated topical agents have led to new treatment paradigms. The 2009 GlobalAlliance toImproveOutcomes in Acne guidelines recommend that mild-to-moderate acne is best treated with retinoid-based topical agents.With the rise of new technologies and in-office procedures, light and laser therapies, photodynamic therapy and chemical peels are growing in popularity as adjunctive treatments, and may offer alternatives to those who desire better efficacy, quicker onset of action, an improved safety profile, and a reduced risk of antibiotic resistance. Chemical peeling is a form of skin resurfacing that induces epidermal or dermal injury followed by


regeneration of the tissues. The success of peeling is crucially dependent on the physician’s understanding of the chemical and biological processes, as well as of the depth of penetration of the peel, clinical effectiveness, and side-effects of the procedure. Microneedle therapy has long been used by dermatologists in the form of collagen induction therapy

(CIT) to fade scars, and generally as an anti-ageing treatment. Smaller sizes of microneedles were then recognised for their capacity to dramatically increase the bioavailability of topical treatments and enhance their transcutaneous absorption.Microneedle technology, as a physical enhancement method, offers a minimally-invasive and painless route of drug administration as microneedles are too short to reach dermal nerves or blood vessels.After treatment, keratinocytes proliferate and release growth factors to promote collagen deposition by the fibroblasts. This technology is currently being used to treat skin conditions such as wrinkles, acne, and burn scars.However, data on safety is insufficient and requires more in-depth study to confirm and establish a consensus of guidelines for use. The initial conception of fractional photothermolysis is one of the most significant milestones in the

field of laser technology and cutaneous resurfacing. Based on the mechanisms of action, non-ablative fractional photothermolysis held great promise in the treatment of skin textural abnormalities and pigment variation, with a lower incidence of adverse effects. Scientific research in the field of energy- and light-based procedures made it possible to develop an innovative generation of lasers that combine the benefit of a non-ablative and a fractional laser device, promising skin rejuvenation without harming the epidermis. This issue of PRIME sheds light on many of the topics most attractive in this area, and which are of increasing interest.

Dr Mohamed L. Elsaie Lecturer inDermatology &CutaneousSurgery,NationalResearchCentre,Cairo; VoluntaryInstructor ofDermatology &CutaneousSurgery, University ofMiami


SPECIALISM Dr Claude Dalle

Dr Wilmar Accursio Dr Pierre Andre Dr Ashraf Badawi

Dr Janethy Balakrishnan Dr Lakhdar Belhaouari Dr Philippe Berros Dr Dario Bertossi

Anti-ageing & aesth. medicine France Endocrinologist Dermatology Dermatology Dermatology Plastic surgery

France Egypt

Malaysia France

Oculoplastic surgery Maxillofacial surgery

Dr Philippe Blanchemaison Phlebology Dr Pierre Bouhanna Dr Fahd Benslimane Prof Wayne Carey

Dr Claude Chauchard Dr Olivier Claude

Dr Christophe de Jaeger Dr Jacques Dequesne Prof Ilaria Ghersetich Dr Kate Goldie

Dr Monika Golkova Prof Eckart Haneke Dr Steven Hopping Prof Xiaoyan Jiang

Prof Andreas Katsambas Dr Mario Krause

Dermatology – Hair surgery Plastic Surgeon Dermatology

Anti-ageing medicine Plastic surgery Geriatrics

Gynaecologist Dermatology

Aesthetic Physician Neurologist Dermatology Plastic surgery Genetics

Dermatology Anti-ageing medicine

Monaco Italy

France France

Morocco Canada France France France France Italy UK

Czech Republic Germany USA

Canada Greece




Dr Marina Landau

Dr Gustavo Leibaschoff Dr Jean-Luc Levy Dr Sohail Mansoor Prof Leonardo Marini


Anti-ageing medicine Dermatology

Cosmetic surgery Dermatology Dermatology Dermatology

Prof Dr Martino Neumann Dermatology & Venereology Prof Daniel Pella Dr Vincenzo Penna


Dr Chariya Petchngaovilai Dermatology Dr Philippe Piccerelle Prof Ascanio Polimeni Dr Herve Raspaldo Dr Neil Sadick

Dr Pakpilai Thavisin Dr Mario Trelles Dr Ines Verner Dr Octavio Viera

Dr Jean-Luc Vigneron Prof Bernard Weber Dr Sabine Zenker

Catherine Decuyper Wendy Lewis

Christophe Luino

Plastic surgery Dermatologist

Neuro-endocrinology Facial plastic surgery Dermatology

Anti-ageing medicine; pediatry Aesthetic dermatology Genetician


Industry expert & consultant Industry expert

Industry expert & consultant


Israel USA

France UK


Netherlands Slovakia Germany Thailand France Italy

France USA

Dermatology & Anti-ageing medicine Thailand Plastic surgery Dermatology

Spain Israel Spain


Luxembourg Germany France USA

France | November/December 2012 ❚ 5

HE LAST 20YEARS HAVE WITNESSED RAPID DEVELOPMENTS IN AESTHETIC medicine and the myriad of non-invasive techniques.Obsession with cosmetic surgery regularly hits headlines globally because of its high take-up rate by both women and men — and even in the most conservative cultures. Acne vulgaris is a common disorder of the pilosebaceous follicle with multiple pathogenic factors.While previous anti-acne treatment algorithms focused on

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