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T HAS BEEN KNOWN FOR MANY years that eating too many foods containing 'bad' fats, such as saturated fats or trans fats, is not healthy for the heart. However, according to new research from Brigham and Women's

Hospital (BWH), one particular 'bad' fat ® saturated fat ® has been found to be associated with a worse overall cognitive function and poor memory in women over time. On the other hand, a 'good' fat ® mono-unsaturated ® was associated with better overall cognitive function and memory. This study has been published online by

Annals of Neurology, a journal of the American Neurological Association and Child Neurology Society. The research team analysed data from the

Women's Health Study ® originally a cohort of almost 40000 women aged 45 years and older. The researchers focused on data from a subset of 6000 women, all over the age of 65 years. The women participated in three cognitive function tests, which were spaced out every 2 years for an average testing span of

Bayer has announced the successful completion of two pivotal European Phase III clinical trials with ATX-101, an injectable drug for the reduction of unwanted fat under the chin. In a top-line analysis of the

study data, ATX-101 demonstrated in the primary endpoint statistically significant efficacy (P<0.001) compared with placebo in the reduction of the fat, as assessed by two primary measures: a 5-point Clinician- Reported Submental Fat Rating

A round-up of news stories in the aesthetic and anti-ageing medicine industry

EFFECT OF DIET ON COGNITIVE FUNCTION Certain types of fat associated with poor memory and overall cognitive function

4 years. These women completed very detailed food frequency surveys at the start of the Women's Health Study, prior to the cognitive testing. 'When looking at changes in cognitive

function, what we found is that the total amount of fat intake did not really matter, but the type of fat did,' explained Olivia Okereke, MD, Department of Psychiatry. Women who consumed the highest

amounts of saturated fat, which can come from animal fats such as red meat and butter, compared with those who consumed the lowest amounts, had a worse overall cognition and poor memory over the 4 years of testing. Women who ate the most of the monounsaturated fats, which can be found in olive oil, had better patterns of cognitive scores over time. 'Our findings have significant

public health implications,' said Dr Okereke. 'Substituting the good fat in place of the bad fat is a fairly simple


Scale (CR-SMFRS) and a 7-point Subject Satisfaction Rating Scale (SSRS).

In addition, in both pivotal trials,

ATX-101 demonstrated statistically significant efficacy (P<0.001) compared with placebo as evaluated by secondary Patient-Reported Outcome Measures (PROMs). These improvements were also confirmed by reductions in submental fat thickness measured using calipers (P<0.025). If approved, ATX-101 will be the

first in a new class of aesthetic drugs to reduce fat under the chin without surgery. The clinical development of ATX-101 is a joint effort by Bayer and KYTHERA. Eugene O’Keefe, MD, Vice

President and Head of Global Development Dermatology at Bayer HealthCare commented: 'ATX-101 represents a promising

candidate for the growing aesthetic medicine market. We have applied the same rigorous and evidence-based development approach to this drug as we

customarily do with our other prescription drugs for the treatment of dermatological diseases and disorders.' Results from both Phase III trials

reflect the findings already observed in previous Phase II trials, where ATX-101 was well tolerated and yielded statistically significant reduction of unwanted submental fat compared to placebo, based on the assessments of clinicians, patients and objective measurements. | June 2012 ❚ 9

dietary modification that could help prevent decline in memory.' Okereke notes that strategies to prevent

cognitive decline in older people are particularly important. Even subtle declines in cognitive functioning can lead to higher risk of developing more serious problems, such as dementia and Alzheimer's disease.

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