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ARTICLE | BODY CONTOURING | Figure 3 (MP)2 treatment to the


thighs before (A) and after (B) eight treatments


ore


Beforetreatment options thus far is that there might be a lack After 8 treatments


of clinical efficacy and almost always a significant level of pain occurring as a result of the treatment. The two acting components of (MP)¨ technology deliver


a new approach for facial and body contouring by tightening the skin, as well as reducing fat pads and treating cellulite. In the past, multipolar RF was shown to be superior to monopolar and bi-polar RF in effectively inducing a sequential electro-thermal tissue stratification effect, improving patient comfort and decreasing side-effects. Pulsed magnetic fields (PMF) have been proven to accelerate angiogenesis, cutaneous wound healing, and bone and nerve repair. PMF also decreases post-surgical pain and oedema, as well as negatively influencing bacterial and tumoural cell growth. Combining these two technologies seems to produce a


synergistically effective dermalÐ hypodermal tissue functional improvement inducing long-term collagen remodelling, adipose tissue reshaping, and cellulite regression. MP¨ technology is the first technical example in


References


1. Salzberg CA, Cooper-Vastola SA, Perez F, Viehbeck MG, Byrne DW. The effects of non-thermal pulsed electromagnetic energy on wound healing of pressure ulcers in spinal cord-injured patients: a randomized, double-blind study. Ostomy Wound Manage 1995; 41(3): 42–8


2. Kloth LC, Berman JE, Sutton CH, Jeutter DC, Pilla AA, Epner ME. Effect of pulsed radio frequency stimulation on wound healing: a double-blind pilot clinical study. In: Bersani F. ed, Electricity and Magnetism in Biology and Medicine. New York: Plenum Press, 1999


3. Mayrovitz HN, Larsen PB. Effects of pulsed magnetic fields on skin microvascular blood perfusion. Wounds 1992; 4: 197–202


4. Mayrovitz HN, Larsen PB. A preliminary study to evaluate the effect of pulsed radio frequency field treatment on lower extremity peri-ulcer skin microcirculation of diabetic patients. Wounds 1995; 7: 90–3


5. Mayrovitz HN, Macdonald J, Sims N. Effects of pulsed radio frequency diathermy on postmastectomy arm lymphedema and skin blood flow: a pilot investigation. Lymphology 2002;


34 ❚ 85: 87–90


6. Pilla AA. Mechanisms and therapeutic applications of time varying and static magnetic fields. In: Barnes F, Greenebaum B. eds, Biological and Medical Aspects of Electromagnetic Fields. Boca Raton: CRC Press, 2006


7. Colomer J, Means AR. Physiological roles of the Ca2+/ CaM-dependent protein kinase cascade in health and disease. In: Carafoli E, Brini M. eds, Calcium Signaling and Disease. New York: Springer, 2007


8. Bruckdorfer R. The basics about nitric oxide. Mol Aspects Med 2005; 26(1–2): 3–31


9. Hagendoor n J, Padera TP, Kashiwagi S et al. Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics. Circ Res 2004; 95(2): 204–9


10. Mariotto S, Menegazzi M, Suzuki H. Biochemical aspects of nitric oxide. Curr Pharm Des 2004; 10(14): 1627–45


11. Tepper OM, Callaghan MJ, Chang EI et al. Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2. FASEB J 2004; 18(11): 1231–3


12. Callaghan MJ, Chang EI, Seiser N et al. Pulsed electromagnetic fields accelerate normal and diabetic wound healing by increasing endogenous FGF-2 release. Plast Reconstr Surg 2008; 121(1): 130–41


13. Geronemus RG. Fractional photothermolysis: current and future applications. Lasers Surg Med 2006; 38(3): 169–76


14. Gilchrest BA. A review of skin ageing and its medical therapy. Br J Dermatol 2007; 135: 867–75


15. Goldberg DJ. Lasers for facial rejuvenation. Am J Clin Dermatol 2006; 4(4): 225–34


16. Capon A, Mordon S. Can thermal lasers promote skin wound healing? Am J Clin Dermatol 2003; 4(1): 1–12


17. Stadelmann WK, Digenis AG, Tobin GR. Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg 1998; 176(2A Suppl): 26S–38S


18. Franco W, Kothare A, Ronan SJ, Grekin RC, McCalmont TH. Hyperthermic injury to adipocyte cells by selective heating of subcutaneous fat with a novel radiofrequency device: feasibility studies. Lasers Surg Med 2010; 42(5): 361–70


Combining these two


which these two innovative biomedical strategies are intimately associated. Both short- and long-term results are very promising and can be seen progressively; after one series of 6–10 treatments, full clinical results will peak at 2–4 months after the last treatment. The first clinical results of this


After 8 tr atments


technologies seems to produce a synergistically effective dermalÐ hypodermal tissue functional improvement inducing long- term collagen remodelling,


adipose tissue reshaping, and cellulite regression.


extremely innovative technique seem to be the next step in micro-invasive tightening and re-shaping procedures in treating patients ® for the first time in this category ® without pain. More clinical studies are nevertheless required to further understand the full potential.


 Declaration of interest None. The author has no competing


interests and did not receive any remuneration from Venus Concept in writing this article.


 Figure images 1 ç Dr Sabine Zenker 2, 3 ç Venus Concept


Key points


■ A number of studies have been conducted to test the efficacy of PEMF therapy for wound and ulcer healing, as well as pain management


■ PEMF has been proven to stimulate the production of collagen fibres and the proliferation of fibroblasts in the dermis, which promote healthier, younger-looking skin, and trigger angiogenesis


■ The two acting components of (MP)2 technology deliver a new approach for facial and body contouring by tightening the skin, as well as reducing fat pads and treating cellulite


June 2012 | prime-journal.com


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