Imaging
Figure 19
Siemens Preclinical Inveon CT system that can also be configured as PET/CT, SPECT/CT or PET/SPECT/CT integrated system
data analysis with Inveon Research Workplace™ (IRW). IAW includes a total of nine PET recon- struction methods, including the recently intro- duced OP-MAP algorithm that delivers high quan- titative accuracy in low-dose imaging. IRW pro- vides a fully integrated workflow for image visual- isation, quantitative analysis and image and data distribution, and is offered with optional upgrades that include pharmacokinetic (PK) modelling and 3D visualisation (3D Vis). The company also offers a broad set of compatible accessories ranging from animal pallets, mouse and rat imaging chambers, physiological monitoring and heating systems and an isoflurane rodent anesthesia system (Figure 19).
systems. The fully-shielded Inveon CT is highly configurable to customer needs and can perform anatomical or high-resolution CT scans, in addi- tion to fast, low-dose CT imaging for longitudinal studies. For added workflow flexibility and throughput, the Inveon platform also offers a unique docking configuration between its stand- alone PET system and CT or SPECT/CT systems. The Inveon platform includes a complete work- flow solution, from acquisition and reconstruction with Inveon Acquisition Workplace™ (IAW) to
In April 2011 in Orlando, Florida, Sofie Biosciences (
www.sofiebio.com) launched the industry’s first benchtop preclinical PET system, GENISYS4, at the American Association for Cancer Research Annual Meeting. With its unprecedented compact size (W18”xD19”xH24”), GENISYS4 can be installed on any laboratory bench with minimal site planning. As PET becomes an essential tool for translational research, Sofie believes it is time for PET technology to be more widely accessible, cost-effective and convenient for integration into a wide variety of labs. To achieve this, it believes PET must reduce its size and com- plexity while increasing usability and performance. GENISYS4 was carefully designed to incorporate Sofie’s vision to meet all these needs. By utilising a new PET detector architecture in conjunction with advanced software system modelling and recon- struction algorithms, GENISYS4 demonstrated unmatched sensitivity (>14%) with high spatial resolution (1.4mm), meaning it is the smallest PET imaging system in the industry, yet the most sensi- tive. The high sensitivity enables researchers to inject less radioactive PET probe into animal mod- els, which will in turn result in less radiation dose to researchers as well. Furthermore, as PET meas- ures physiology of the animal, Sofie believes the animal’s condition should be carefully maintained and monitored over the course of the experiment. GENISYS4 also provides solutions for these needs by employing a novel animal preparation stage called the Docking Station which is integrated with its Imaging Chamber. In addition, the animal res- piratory monitoring capability ensures the animal’s condition during the study. Sofie hopes GENISYS4 will enable more investigators to incorporate PET into their research (Figure 20).
Figure 20: Sofie Biosciences recently launched GENISYS4 benchtop preclinical PET system. With the highest sensitivity in the field, researchers can inject less radioactive PET probe into animal models, which will in turn result in less radiation dose to researchers as well
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The UVP iBox® Explorer™ Fluorescence Imaging Microscope (
http://www.uvp.com/iboxexplorer.
Drug Discovery World Summer 2011
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