Imaging
application areas including cancer research, neuro- biology, obesity and diabetes, in vivo and ex vivo (ie 3D histology) anatomical imaging. The system can leverage a variety of techniques including 2D, 3D and contrast agent acquisition and analysis in addition to participating easily in multi-modality applications and image co-registration (Figure 10).
Figure 10: Multi-slice image sequence of Human Glioma in an adult mouse brain using the Aspect Imaging M2 quantitative MRI system. (Image sequence courtesy of Dr A Johnson, Duke University, NC)
fields. The Aspect’s M2 system solves all these issues as it is affordable to purchase, is virtually maintenance-free, has no active magnetic field so it can be placed anywhere in a research lab and has been designed to be operated by researchers with no prior imaging or MRI experience. Because of this simplicity of operation, the power of MRI as a diagnostic standard is now available to be applied to complex biological questions in many research
The new easy-to-use indiGO software for in vivo imaging available from Berthold Technologies (
www.berthold.com) for the NightOWL LB 983 has been developed together with users and covers a broad range of laboratory situations. Only three but- tons: applications and templates; projects and analy- sis; and acquisition and scheduling; guide users intu- itively through the software. Well organised menus and dialogue boxes help set up experiments easily. All images are saved immediately. The workflow of an application is scheduled by drag and drop. Individual exposures of bioluminescence or fluores- cence as well as multi-fluorescence measurements in combination with bioluminescence measurements are possible for different sequences/kinetics. Pre- and post settings for each acquisition are also possible to allow highest flexibility. Multi-fluorescence measure- ments are shown in different colours according to the used filters. Most effort was spent on the analysis menu. Latest image processing methods such as transparency, combined contrast settings or image overlay have been implemented. The apply function is easy to use and time-saving, as the user selects one image out of the whole measurement series and edits it according to his needs. Afterwards the user applies their chosen settings to all images of the whole meas- urement series per mouse click. The data export to Excel is done automatically. Different user rights from guest level up to administrator can be imple- mented, eg to apply new projects, do measurements or evaluations. indiGO software can be installed free of charge on different PCs to allow image analysis at different places. Images from the former WinLight software can be imported for easier data evaluation (Figure 11).
Figure 11: Screenshot of the new indiGO software for in vivo imaging now available on Berthold Technologies’ NightOWL LB 983
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Bioscan (
www.bioscan.com) is a leading supplier of preclinical nano-tomographic molecular imaging tools that enable significant breakthroughs in the discovery, validation and development of novel therapeutics. The unique imaging acuity enabled by its proprietary technologies make it possible to translate research results from small animal models of human diseases to human clinical trials – driving increased speed to market for drugs. Bioscan’s industry-leading nuclear imaging systems generate quantitative, 3D images of biotracers in animals
Drug Discovery World Summer 2011
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