Contents


DDW the quarterly business review of drug discovery & development


Publisher and Editor-in-Chief Robert Jordan Robert@rjcoms.com


Consultant Editor Dr Roger Brimblecombe


Contributing Author Dr John Comley


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Drug Discovery World (USPS 018-892) is published four times a year by RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8ET, United Kingdom. Tel: +44 (0)20 8487 5656 Fax: +44 (0)20 8487 5666 E-mail: Robert@rjcoms.com


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© 2011 RJ Communications & Media Ltd All rights reserved. ISSN 1469-4344


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dr ug discov er y wo r l d contents


VOLUME 12 ISSUE 3 ● SUMMER 2011 Introduction


Dr Roger Brimblecombe Consultant Editor


Therapeutics


Present and Future Challenges in Type 2 Diabetes Dr Lesley J Millat, Dr Remy Hanf and Dr Dean W Hum


Business


What are the Obstacles to Innovation in the Pharmaceutical Industry The Pistoia Alliance


Drug Discovery


Keeping ahead of the flow – Can the next generation of flow chemistry and biology platforms be fully integrated to transform the efficiency of small-molecule drug discovery for pharmaceutical industry? Dr J Mark Treherne, Dr David M Parry and Christopher N Selway


Biomarkers


The Sooner the Better – Utilising Biomarkers to Eliminate Drug Candidates with Cardiotoxicity in Preclinical Development Dr Frederica Crivellente


Drug Discovery


The Need for High Throughput Kinetics Early in the Drug Discovery Process Dr Wilma Keighley


Personalised Medicine


Early Patient Stratification is Critical to Enable Effective and Personalised Drug Discovery and Development Dr David A Fryburg, Dr Diane H Song and Dr David de Graaf


Imaging In Vivo Preclinical Imaging – An Essential Tool in Translational Research Dr John Comley


Informatics


Selecting a LIMS for Next-Generation Sequencing Research Bruce Pharr and Dr Michael Kuzyk


Therapeutics In Vivo Cell Reprogramming – Current Status and Potential Clinical Applications Dr Shili Wu, Jonathan Pang, Bobby Baravati, Jun Bao and Dr Yong Zhu


Front cover illustration courtesy of Adam Hart-Davis/Science Photo Library Drug Discovery World Summer 2011 5


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