Drug Discovery
or administration to patients. New approaches must be developed to efficiently manage this fill/finish process for stem cells.
The road ahead
Stem cells represent seemingly limitless application in the clinical setting and can offer greater efficien- cy and physiological relevance to the drug discov- ery and development process. Yet along with this great promise come numerous challenges. While significant progress has been made, there is still much to do. Taking full advantage of the unique properties of stem cells will require a greater understanding of their inner workings as well as innovative technology to enable large-scale, consis- tent production.
DDW
Dr Jeffrey Till is director of EMD Millipore’s Stem Cell Initiative, a programme focused on developing the tools and technologies required to enable large- scale, industrialised production of stem cells. Prior to joining EMD Millipore, Jeff was Scientific Director at Upstate Biotechnology; prior to this, he was at Exelixis.
Robert Shaw is commercial director of EMD Millipore’s Stem Cell Initiative. Prior to joining EMD Millipore, Robert was Director of Commercial Development at Wyeth Biopharma.
Drug Discovery World Spring 2011 23
References 1 EMD Millipore. ENStem-A Adherent Human Neural Progenitors: A New Source of Primary Human Neural Cells. Application Note. 2008. 2Takahashi, K, Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126, 633-76. 3 Baker, M. Integration-free iPS cells. Nature Reports Stem Cells. October 16, 2008. 4 Sommer, CA et al. iPS cell generation using a single lentiviral stem cell cassette. Stem Cells. 2009 Mar;27(3): 543-9. 5 Sommer, CA, Gianotti Sommer, A, Longmire, TA, Christodoulou, C, Thomas, DD, Gostissa, M, Alt, FW, Murphy, WJ, Kotton, DN, Mostolslavsky, G. Excision of reprogramming transgenes improves differentiation potential of iPS cells generated with a single excisable vector. Stem Cells 2010, 28(1), 64-74. 6 Somers, A, Jean, JC, Sommer, CA, Omari, A, Ford, CC, Mills, JA, Ying, L, Sommer, AG, Jean, JM, Lafyatis, R, Demierre, MF, Wiess, DJ, French, DL, Gadue, P, Murphy, GJ, Mostoslavsky, G, Kotton, DN. Generation of transgene-free lung disease- specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette. Stem Cells. 2010 Oct;28(10):1728-40. 7 Guidance for Industry: Drug- induced Liver Injury. US Department of Health and Human Services. July 2009. 8 McKernan, R, McNeish, J and Smith, D. Pharma’s developing interest in stem cells. Cell Stem Cell 2010. 6, 517-520.
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