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nanotimes
News in Brief
10-04 :: April 2010
Tools //
A Tiny Molecular Switch That Turns Itself On Or Off As It Detects Metallic Ions
T
wo chemists at The Scripps Research Institute
have synthesized a new nano-scale scientific
tool – a tiny molecular switch that turns itself on or off as it detects metallic ions in its immediate sur- roundings.
This molecule may be useful as a laboratory tool for controlling tiny reactions in the test tube, and it has potential to be developed as the basis of a new tech- nology that could sensitively detect metals, toxins, and other pollutants in the air, water, or soil. The molecule is named “ouroborand” after the mythical Ouroboros (“tail-eater” in Greek) – a lizard-like cre- ature that swallows itself head-to-tail. In mythology, the cyclic Ouroboros is always depicted with its tail in its mouth and this is usually taken as a symbol of eternity. In the Scripps Research laboratory where it was invented, the ouroborand molecule alternatively swallows or coughs out its tail-like a switch that goes on or off as it senses metals.
This switching is possible because the molecule has a cup-like head at one end and a tail at the
other. The tail can curl around and plug the cup – just like the lizard swallowing its own tail.
“When no metals are present, the molecule‘s tail is held within its cavity at the other end,” says Juli- us Rebek, Ph.D., who is the director of the Skaggs
Institute for Chemical Biology at Scripps Research. In the presence of zinc or other metal ions, the part of the molecule that links the head and the tail curls around the metal ions and pulls the head and the tail apart, springing the molecule open, says Rebek. Re- move the metal, and the tail will move again to plug the other end of the molecule. When Rebek and his postdoctoral fellow Fabien Durola synthesized the molecule and decided to name it ouroborand, they made a return of sorts to the dreams of chemists and alchemists long ago. In Medieval times and through the Renaissance, the mythical Ouroboros was a sym- bol used in alchemy, the ancient practice that was a forerunner to modern chemistry.
The spirit of this symbol later briefly carried over into modern chemistry as well. More than a century ago, the famous German chemist August Kekule had a dream about a serpent with its tail in its mouth, and this inspired him to propose the correct, circular structure of the compound benzene, a commonly used industrial solvent.
Fabien Durola and Julius Rebek: The Ouroborand: A Cavi- tand with a Coordination-Driven Switching Device, In: An-
gewandte Chemie International Edition, Volume 49, Issue
18, Pages 3189-3191, DOI:10.1002/anie.200906753:
http://dx.doi.org/10.1002/anie.200906753 http://www.scripps.edu/skaggs/rebek/
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