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Contents


DDW the quarterly business review of drug discovery & development


Publisher and Editor-in-Chief Robert Jordan Robert@rjcoms.com


Head of Digital Giles Jordan


Consultant Editor Dr Roger Brimblecombe


Design & Production Melissa Chadderton rhubarbcreative@sky.com


US Advertising Manager Jonathan Sismey Jonathan@rwwcompany.com


Editorial Advisors Dr Steve Arlington Dr Nigel Brown Dr Rathnam Chagaturu Dr David Clough Dr Richard Eglen Dr Gregory Lennon Dr Keith Mansford Dr Stephen Naylor Dr George Poste Dr Amber Salzman Dr David U’Prichard Dr Timothy Wells Dr Rene Ziegler


Drug Discovery World (ISSN 14694344) is published quarterly by RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8EL, United Kingdom. Tel: +44 (0)20 8487 5656 Fax: +44 (0)20 8487 5666 E-mail: Robert@rjcoms.com


The US annual subscription price is USD140. Airfreight and mailing in the USA by agent named WN Shipping USA, 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA. Periodicals postage paid at Jamaica NY 11431. US Postmaster: Send address changes to DRUG DISCOVERY WORLD DDW, WN Shipping USA, 156- 15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA. Subscription records are maintained at RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8EL, United Kingdom. Air Business Ltd is acting as our mailing agent.


© 2020 RJ Communications & Media Ltd All rights reserved.


No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the copyright holder. While the publishers believe that all information contained in this publication was correct at the time of going to press, they can accept no liability for any inaccuracies that may appear or loss suffered directly or indirectly by any reader as a result of any advertisement, editorial, photographs or other material published in Drug Discovery World.


d r u g d i s c o v e r y wo r l d contents VOLUME 21 ISSUE 1 ●WINTER 2019/20


Introduction Dr Roger Brimblecombe Consultant Editor


Drug Discovery Cryo-EM Accelerates Drug Discovery by Delivering Previously Intractable Structural Insights Hans Raaijmakers, Dr Mazdak Radjainia, Dr Hervé-William Remigy and Aleksandar Stefanovic


Laboratory Automation Getting a Handle on Liquids: Automation Solutions for Drug Discovery Helen Stewart-Miller and Thomas Hope


Therapeutics Unlocking the Potential of Extracellular Vesicles: From Single Molecules to Novel Therapeutics Dr Anna Caballe and Dr Katarzyna Ginda-Makela


Precision Medicine Harnessing the Modified Proteome for Increased Diagnostic Power Dr David Bramwell, Dr Steven Laval and Dr Jane McLeod


Business 2030: Life Sciences and Health in the Digital Age – Part 2 Dr Steve Arlington and John Wise


Drug Development +Drug Development 2.0: The Partnership Model in Practice Dr Mark Roberts and Dr Sam Genway


Informatics Evolution of User Experience for Life Sciences Jacek Ziemski, Simon Fortenbacher, James Hoeksma, Jan Taubert, Roger Atrill, Paula de Matos, Andre Richter and Julie Morrison


7 9


17 26


33 41 52 59


Front cover illustration courtesy of Victor Habbick Visions/Science Photo Library Drug Discovery World Winter 2019/20 5


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