Push the boundaries of structural biology with cryo-electron microscopy


Ternary GPCR complex of biased agonist-bound GLP-1 receptor. DOI: 10.1038/nature25773


Cryo-electron microscopy for drug discovery Thermo Scientific™


cryo-electron microscopes allow the structure determination of proteins and macromolecular


complexes at near-atomic level. This enables the study of biomolecular function and interaction, helping researchers better understand disease mechanisms and possibly leading to targeted drug discovery.


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2 Thermo Scientific Krios™ G4 Cryo-TEM Thermo Scientific Glacios™ Cryo-TEM


Figure 1. Structures of Ebola virus GP and sGP in complex with therapeutic antibodies. DOI: 10.1038/NMICROBIOL.2016.128. Figure 2. Cryoelectron Microscopy Maps of Human Papillomavirus 16 Reveal L2 Densities and Heparin Binding Site. DOI: 10.1016/j.str.2016.12.001


Find out more at pharmadrugdiscovery.com/cryo-em-solutions


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