Contents
DDW the quarterly business review of drug discovery & development
Publisher and Editor-in-Chief Robert Jordan
Robert@rjcoms.com
Head of Digital Giles Jordan
Consultant Editor Dr Roger Brimblecombe
Design & Production Melissa Chadderton
rhubarbcreative@sky.com
US Advertising Manager Jonathan Sismey
Jonathan@rwwcompany.com
Editorial Advisors Dr Steve Arlington Dr Nigel Brown Dr Rathnam Chagaturu Dr David Clough Dr Richard Eglen Dr Gregory Lennon Dr Keith Mansford Dr Stephen Naylor Dr George Poste Dr Amber Salzman Dr David U’Prichard Dr Timothy Wells Dr Rene Ziegler
Drug Discovery World (ISSN 14694344) is published quarterly by RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8EL, United Kingdom. Tel: +44 (0)20 8487 5656 Fax: +44 (0)20 8487 5666 E-mail:
Robert@rjcoms.com
The US annual subscription price is USD140. Airfreight and mailing in the USA by agent named WN Shipping USA, 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA. Periodicals postage paid at Jamaica NY 11431. US Postmaster: Send address changes to DRUG DISCOVERY WORLD DDW, WN Shipping USA, 156- 15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA. Subscription records are maintained at RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8EL, United Kingdom. Air Business Ltd is acting as our mailing agent.
© 2019 RJ Communications & Media Ltd All rights reserved.
No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the copyright holder. While the publishers believe that all information contained in this publication was correct at the time of going to press, they can accept no liability for any inaccuracies that may appear or loss suffered directly or indirectly by any reader as a result of any advertisement, editorial, photographs or other material published in Drug Discovery World.
d r u g d i s c o v e r y wo r l d contents VOLUME 20 ISSUE 4 ● FALL 2019
Introduction Dr Roger Brimblecombe Consultant Editor
Informatics Unlocking Clinical Trial Data to Uncover New Therapeutic Opportunities – Key Considerations and Best Practices David Wang, Masha Hoffey and Dr Simone Sharma
Drug Discovery Bitten By the Bug – A Flurry of Investments Fuels Microbiome Drug Discovery Dr Alexander C. Maue
Imaging Using Live-Cell Imaging Systems to Transform Perspective in Drug Discovery Helen Stewart-Miller and Dr Kate Tointon
Informatics How Artificial Intelligence is Transforming Drug Design Dr Mark Roberts and Dr Sam Genway
Screening Optimising Phenotypic Screening: Single-Cell Analysis Versus 3D Multicell Analysis Dr Richard M. Eglen
Business 2030: Life Sciences and Health in the Digital Age Dr Steve Arlington and John Wise
Screening Reducing the PAINS in Hight Throughput Screening: Assay Design as a Tool for Maximising Efficiency Dr Philip S. Jones and Dr Stuart P. McElroy
Therapeutics Evolving Models for NASH Drug Discovery: Tools for Stemming a Silent Epidemic Dr Sue Grepper, Dr Radina Kostadinova, Dr Eva Thomas and Professor Armin Wolf
7 9
15 20 29
37 43
61 53
Front cover illustration courtesy of Gilles Mermet/Science Photo Library Drug Discovery World Fall 2019 5
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68
