Imaging
microplates. The monitor can be used across a wide range of applications, including cell migra- tion, wound healing and scratch assays analysis, stem cell behaviour studies and chemotaxis stud- ies.
The CytoSMART™ Omni is an automated live-
cell imager small enough to fit in any regular cell- culture incubator. The system is capable of imag- ing a complete T-flask or well plate by taking 6,500 high magnification digital phase contrast images at predefined time intervals. The system comes with a CytoSMART™ Connect Cloud, which is a suite of image analysis software for high volume confluency analysis, colony detection and scratch assays. The CytoSMART™ Connect Cloud runs on
Microsoft Azure, which provides cost-efficient, large storage capacity and high levels of processing power for analysing and storing images. The plat- form is accessible from any computer, tablet or mobile phone to enable remote, real-time monitor- ing. It can also be set up to send automatic notifi- cations to users once the cell-culture has reached the confluency threshold (Figure 1).
Figure 1: The CytoSMART Lux2 live-cell monitor (above) and CytoSMART Omni automated live-cell imager (below)
Etaluma Lumascopes – real microscopy simplified Etaluma’s technology centres on a compact and simple optics path allowing lower power fluores- cence excitation for the avoidance of photo dam- age. The solid state filter design eliminates pixel shift between channels and real phase contrast pro- vides high quality transmitted light images. An open design allows fluidics and micro injectors to be integrated. Magnifications from 2.5x to 100x are available for research quality images. All four Lumascope models can be placed in
environmental chambers, including common cell- culture incubators, as well as hypoxia chambers and refrigerators. Additionally, tiling and z-stack- ing capabilities help to keep the cells of interest within the image during time-lapse experiments (Figure 2).
PerkinElmer – application flexibility for all throughputs The new PerkinElmer MuviCyte™ live-cell imag- ing system is designed to operate inside an incuba- tor to enable long-term observations under con- trolled conditions. The system can scan a broad range of vessel types and is compatible with label- free transmitted light readout as well as three- channel (red, green, blue) fluorescent imaging to enable a wide range of commonly-used live-cell assays (Figure 3). The PerkinElmer Opera Phenix™ and Operetta
22 Drug Discovery World Fall 2019
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