DECONTAMINATION
Breaking COVID transmission with biocide
Adrian Gee-Turner discusses the survival of SARS-CoV-2 on surfaces, the risk of transmission, and the efficacy of hypochlorous acid in killing the virus.
As the pandemic progressed, our understanding of the virus that causes COVID-19 grew, and this has influenced the guidance on transmission prevention measures such as face masks, social distancing, hand washing and disinfection. While a few grey areas persist, such as the degree of challenge presented by aerosolised virus, a number of conclusions are emerging. Fomite transmission: Fomite transmission (from objects and surfaces) is highly likely given the extended periods (days) that SARS-CoV-2 is able to remain viable on a variety of surfaces, including glass and plastic. This is important because people generally touch mobile phones and keyboards many times per day – so, as well as hand washing, touch points will need frequent disinfection with an antiviral disinfectant (caution: some ‘antibacs’ are not antiviral). Temperature: It appears that the viability
of SARS-CoV-2 is significantly reduced by sunlight or high temperatures. This conclusion would appear to be borne out by the outbreaks that have occurred in chilled food packing facilities. Aerosol: SARS-CoV-2 can remain infectious as an aerosol for at least several hours. This is important because pathogens predominate in small particles of less than 5 microns (<5 µm) which do not settle in the way that larger particles do.
Virus survival on surfaces The emergence of a novel human coronavirus, SARS-CoV-2, prompted a review of the available data on the persistence of coronaviruses on inanimate
mentioned that temperatures of 30˚C or higher reduce the duration of persistence.
surfaces and their inactivation with biocidal agents. Published in January 2020, in the Journal of Hospital Infection, the review examined 22 studies that evaluated the persistence of human coronaviruses, such as Severe Acute Respiratory Syndrome (SARS or SARS-CoV-1) coronavirus and Middle East Respiratory Syndrome (MERS) coronavirus.1 The assessment detailed the persistence of coronaviruses on inanimate surfaces such as metal, glass and plastic, but found that they can be efficiently inactivated by surface disinfection procedures. It proposed, therefore, that such procedures should be adopted to curtail the further spread of SARS-CoV-2. Interestingly, while the paper concluded that human coronaviruses can remain infectious on inanimate surfaces at room temperature for up to nine days, it also
Fomite transmission (from objects and surfaces) is highly likely given the extended periods (days) that SARS-CoV-2 is able to remain viable on a variety of surfaces, including glass and plastic.
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Is SARS-CoV-2 different? In general, the health effects of infection by SARS-CoV-1 are more serious than by SARS-CoV-2 but, as a contagion, SARS- CoV-2 is more important because it appears to transmit more easily than its predecessor. This is likely to be because the viral load is highest in the nose and throat of people with COVID-19 shortly after symptoms develop, whereas with SARS, viral loads peak much later in the illness. Consequently, people with COVID-19 may be transmitting the virus even before their symptoms develop. According to the Centers for Disease Control and Prevention (CDC), some research suggests that COVID-19 can be spread by people with no symptoms.
In March 2020, at about the same time that the UK lockdown was first announced, van Doremalen and others published a paper in the New England Journal of Medicine, which compared the aerosol and surface stability of SARS-CoV-2 with SARS-CoV-1. The work assessed the viability of the viruses in five conditions: in aerosols, and on plastic, stainless steel, copper, and cardboard. All of the trials were conducted at 40% relative humidity and 21-23˚C and found that the stability of SARS-CoV-2 was similar to that of SARS-CoV-1 under the experimental circumstances tested.2
The research showed
that SARS-CoV-2 was more stable on plastic and stainless steel than on copper and cardboard, and viable virus was detected up to 72 hours after application to these surfaces, although the virus titer (viral load) was greatly reduced. The results indicated that aerosol and fomite transmission of SARS-CoV-2 is plausible, since the virus can remain viable and infectious in aerosols for hours and on surfaces up to several days.
Airborne transmission Clearly, more work is necessary to better understand the airborne behaviour of the virus. However, a study of the particle sizes
FEBRUARY 2021
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