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TIME TO CHANGE THE WAY WE DO CHEMISTRY AS RADLEYS LAUNCH THE MYA 4 REACTION STATION


Chemistry is becoming more productive than ever before, as UK manufacturer Radleys launch their new Mya 4 Reaction Station.


Mya 4 is a four-zone reaction station that offers precise heating, active cooling, software control and data logging for 24/7 unattended chemistry.


The new Reaction Station allows for multiple experiments with individual control in a single compact benchtop system. Mya 4 provides ultimate flexibility: independent control over four zones, with active cooling and heating from -30 °C to +180 °C, a wide choice of vessels from 2ml to


OGT EXPANDS NGS CANCER PANELS ENABLE SEQUENCING OF DIFFICULT GENES


Oxford Gene Technology (OGT), The Molecular Genetics Company, has expanded its SureSeq myPanel NGS Custom Cancer Panel content. The expansion comes in response to NGS becoming ever more important for research into an increasing number of cancer types, and a need to obtain reliable data for difficult-to- sequence genes and mutations. The expanded content now covers over 70 genes, with many more available in the near future, optimised for haematology and solid tumours including breast, colorectal, lung, ovarian and prostate cancer, glioma, melanoma, sarcoma, leukaemias, myeloproliferative neoplasms and myelodysplastic syndrome.


The strength of OGT’s hybridisation- based bait design coupled with its unique expertise delivers excellent whole gene coverage, unparalleled uniformity and the ability to


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sequence even the most difficult of regions. This yields reproducible and meaningful data, enabling researchers to be confident in sequencing results and analyses.


Some of the most difficult cancer- associated genes to sequence are those that have high levels of GC- rich content, such as the tumour suppressor gene CEBPA in acute myeloid leukaemia, and TP53, which is frequently mutated in many cancer types including breast cancer. In addition, genes that contain internal tandem duplications are challenging to target due to their repetitive nature and length. Panels available from other suppliers can experience problems with data variability, coverage drop-out or masked mutations in these regions.


In contrast, OGT’s innovative bait design uniquely overcomes these issues, delivering the high levels of uniform coverage required, and reducing the need for supplementary fill-in by Sanger sequencing.


This unique design allows researchers to detect low frequency variants consistently down to 1% VAF (variant allele frequency) at a read depth of >1000x. The panels are fully customisable—researchers can select the gene, exonic or intronic content needed to create an NGS cancer panel that meets their exact requirements. All the content is fully pre-optimised, removing the need for lengthy in-house optimisation, reducing assay development time.


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400ml, and magnetic or powerful overhead stirring.


The versatile Reaction Station allows users to have more control over their chemistry than ever before. Round the clock unattended software control will increase safety and productivity, while reducing manual errors for better reproducibility and precision.


The intuitive touch-screen control pad means chemists can set experimental profiles for each individual zone, set safety limits, view real-time results and much more, with an easy-to-use interface that automatically logs all of the data in an exportable CSV format.


Users can select the optional Mya PC Control Software, which allows integration and control over multiple third party devices such as syringe pumps, balances, vacuum pumps and pH sensors etc. on one screen. Experimental recipes and detailed reports can be exported and shared, with everything run from a PC.


Mark Radley, Managing Director of Radleys, commented: “Our team of expert engineers and chemists have sought to solve the problem of multi- tasking chemistry with Mya 4.


The system is designed so a single or multiple users can independently run experiment in 4 zones, each with very different parameters.


Safer and more productive chemistry is at the heart of everything we do at Radleys. Mya 4 also allows chemists to automatically log and control experiments; improving safety, reproducibility and reducing manual errors.


Mya 4 is a flexible and versatile reaction station, allowing chemists to easily manage complex multi-step and multi-device experiments. We look forward to enabling increased productivity in the world of chemical research.”


www.radleys.com/mya4


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