7 Particle Characterisation
Versatile Light Scattering System for Research Applications
The BI-200SM goniometer from Testa Analytical Solutions eK has been designed to make it the finest instrument available for research applications of light scattering.
Offering unmatched performance for both Static Light Scattering (SLS) and Dynamic Light Scattering (DLS) experiments the BI-200SM research goniometer is a precision instrument for undertaking exacting measurements
Favoured by leading research groups around the world, the BI-200SM’s modularity makes system expansion simple. Featuring a standard optical rail, the BI-200SM can be used with neutral density filters, polarisers, auxiliary analysers, additional lasers, and a reference detector. Research groups with special sample requirements can often be accommodated by changing the cell holder design or size.
Based on a special turntable with precision ball bearings and stepping motor, the Bl-200SM’s advanced design and quality construction guarantee precise measurements due to the wobble-free movement of the detector. The system is field proven in hundreds of laboratories and has become a light scattering research standard for macro-molecular studies and submicron particle sizing.
By taking advantage of the multiple inputs available on the BI-200SM’s proprietary digital correlator a new capability of the BI-200SM system was created. By adding an optical signal splitter to the beam of scattered light and a second detector it is possible to eliminate the effects of very high-speed interference from the detector(s). This Cross Correlation System provides remarkably clean data.
More information online:
ilmt.co/PL/1zQB 57943pr@reply-direct.com
Low Field NMR Instrument for Complex Nanoparticle Suspension Characterisation
The Mageleka Magnometer XRS is ideal for routine analysis of complex multi-component nanoparticle solid-liquid and liquid-liquid formulations using non-invasive technology based on NMR proton relaxation.
In every industrial application a knowledge and understanding of the molecular structure and dynamics at the particle-liquid interface is critical to improving or optimising suspension and emulsion product performance at every stage from initial formulation to final manufacture. The Magnometer XRS provides direct information about the extent and nature of any particle-liquid interface of suspensions and emulsions in a matter of minutes.
Measurements with the Magnometer are simple and easy, the sample is placed into a standard NMR tube and then inserted into the MagnoPod©, the test sequence is then initiated and the result reported in under 2 minutes. An exceptionally wide concentration range of 0.01% to 90+% with small sample size of 0.1mL or less and with little or no sample preparation, the Magnometer is perfect for routine analysis of particles suspended in solvents and melts regardless of shape and size. With no prior NMR experience required, the Magnometer is suitable for chemists, technicians or plant workers. The separate magnet assembly allows for remote or glove box operation, an optional programmable temperature-controlled unit is idea for environments where temperature stability is required. The technique is non-destructive so perfect for long term studies.
Applications include batch-to-batch reproducibility in a manufacturing environment, formulation development, kinetic processes, surfactant and competitive surfactant adsorption, aggregation and flocculation, sedimentation studies, presence of para- and ferro-magnetic impurities, oxygen and water content of solvents, molecular weight of polymers in solution polymer and solvent viscosity and additive studies.
Industries served include catalyst, pharmaceutical and personal health care providers, paints. Pigments and coatings, ceramics, refractories, agro chemicals, cosmetics, batteries, electronics, nano medicine and graphene/graphene oxides.
More information online:
ilmt.co/PL/1z99 57895pr@reply-direct.com
Absolute Molar Mass, Size and Conformation of Peptides, Proteins and Polymers
SEC-MALS is essential for accurate determination of molar mass and size. With the addition of one of Wyatt Technology’s DAWN®, miniDAWN® or microDAWN® MALS instruments downstream of the column, a standard HP-SEC systems becomes a SEC-MALS system - now capable of much more than just relative molar mass analysis. In fact, SEC-MALS is the foundation for determining multiple molecular properties, and Wyatt’s MALS detectors are widely recognised as the gold standard for reliable characterisation of macromolecules in solution.
Molar mass: The MALS detector analyses each fraction independently of elution volume. Wyatt’s ASTRA® chromatography software combines MALS signals with those from a concentration detector such as UV/Vis or differential refractometer (dRI) to calculate molar mass from first principles. The results include differential and cumulative distributions, moments and polydispersity. Unlike conventional SEC, SEC-MALS will immediately reveal if a chromatographic peak is homogeneous or polydisperse, regardless of peak width, since it determines molar mass absolutely, every second or so of elution time.
Wyatt’s flagship DAWN MALS instrument measures molar mass from 200 g/mol to 109 g/mol with extraordinary sensitivity: it requires as little as 10 nanograms of 100 kDa polystyrene injected on a standard SEC column.
MALS also measures rms radius (a.k.a. radius of gyration), from 10 nm and up to 500 nm. It accomplishes this even without a concentration detector, since size is determined solely from the angular variation of the scattering.
When the analytes are below 10 nm in radius, Wyatt offers other options. One is online dynamic light scattering (DLS), embedded in the MALS instrument, which can measure hydrodynamic radii from 0.5 nm to 50 nm and beyond. The other is differential viscometry using Wyatt’s ViscoStar detector, which is often added for polymer analysis. ASTRA determines hydrodynamic/viscometric radii of polymers by combining molar mass from MALS with specific viscosity from the ViscoStar.
ASTRA combines molar mass and size information to evaluate the conformation of polydisperse macromolecules such as polymers or polypeptides.
Combining MALS with two concentration detectors - UV and dRI - enables analysis of binary conjugates such as glycoproteins or block co-polymers. The molar mass of each constituent is determined along with the total molar mass for each eluting fraction. More information online:
ilmt.co/PL/EoLw
55770pr@reply-direct.com
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