44 Powerful Platform for Multiphasic Flow Chemistry Reactions


A new paper from Asynt, written by a multidisciplinary team of experts at the Institute for Process Research and Chemistry (iRPD) at the University of Leeds, describes how the fReactor flow chemistry system with add-on photochemical flow modules improves synthetic reactions commonly used in the preparation of drug intermediates.


In contrast to many tubular or plate-based flow chemistry systems, the Asynt fReactor with Photo Flow modules is especially well-suited to handling multiphasic solid-liquid and gas-liquid photochemical reactions.


The new paper describes a series of multiphasic Flow Chemistry reactions undertaken by iRPD researchers using the fReactor Photo Flow platform. Experimental data is provided for a series of relevant reactions including a benzylic bromination with a subsequent nucleophilic substitution step used in the synthesis of the anti-hypertensive drug Valsartan; a reaction where a reagent is used in slurry form to minimise solvent use resulting in significantly higher productivities that would otherwise be possible, an efficient oxidation reaction using air as a simple and safe oxidising agent, and photochemical synthesis of 1,2-diamines with productivities of over 50 times that possible by batch chemistry protocols.


Dr Francis from the iPRD commented: “The fReactor Photo Flow has provided us with an easy-to-use, powerful platform to undertake high productivity photochemistry in Flow Chemistry applications. Integrating the efficiency of flow processing with the advanced mixing of a continuous stirred tank reactor, we have found fReactor Photo Flow to be well-suited to performing multiphasic reactions allowing our chemists to explore continuous-flow processing, with little expertise required.”


The iPRD (https://www.iprd.leeds.ac.uk/) has a long track record of working with industry in developing chemical processes and equipment and in translating findings back to partners. In the described research - iPRD Professors Blacker, Marsden and Kapur, together with Dr Francis who carried out the practical work, worked closely with industry partners - Sterling Pharma Solutions and Redbrick Molecular - to identify relevant reactions to test the performance of the fReactor Photo Flow platform, before optimising reaction conditions.


Download a copy of the new iRPD paper: ilmt.co/PL/Q2rR More information online: ilmt.co/PL/kqem


58246pr@reply-direct.com


Automated Barcode Applicator for Microplates and Petri dishes


Porvair Sciences announce eGecko² - an automated barcode application system that provides the ideal high throughput solution for precisely applying barcode labels onto racks of plates and Petri dishes.


Based upon a robust and proven label printer and print engine, the eGecko² is a completely integrated printer and application unit in one, requiring only an electrical supply for operation.


A choice of easily exchangeable operating heads allows you to apply labels on both flat and curved surfaces. Programmable Z axis motion control application macros allow the eGecko² to automatically adjust between plate types (shallow to deep well) and Petri dishes and then position and apply the labels accordingly.


Powerful, yet highly intuitive software enables the creation of label position and the ability to run the eGecko² automation simultaneously. Integrated third party software, Bartender, is used to directly drive data to the printer. Alternative data can be used upon request.


Using its fully integrated PC, eGecko² enables you to connect to your network LIMS system to allow live data transfer and validation of application labels. Running in the on-board optional verification mode, eGecko² allows you to print and verify all labels to ensure no unreadable labels enter your workflow.


More information online: ilmt.co/PL/Y0Jp 58346pr@reply-direct.com


Auxiliary Air Fume Hood


Zero room air requirements. Hemco Corporation’s fume hood exhaust is equal to the auxiliary supply air, thereby zero room air is required. With the sash in the ½ open position and face velocity of 100 feet per minute, the cfm required equals the air supply. The hood exhaust air plus auxiliary air make up for room supply deficiencies. Auxiliary air fume hoods provide energy savings.


When there is a shortage of air in the lab, it is less costly to provide an auxiliary air fume hood system than to change or enlarge the whole building air handling system. With the sash in the ½ open position it only requires 50% supply air to make up for the exhaust air, making it 100% efficient with no room air required. Supply air ducting and remote blower required. Auxiliary Air fume hoods are available in 4’, 5’, and 6’ widths. All electrical components and services are UL and CSA listed. Shown with optional service fixtures, plumbing and electrical, airflow monitor, work surface and base cabinet.


More information online: ilmt.co/PL/Q2gJ 58166pr@reply-direct.com


Integrated Solution for Multi-modal In Situ Lab SEM


Zeiss is introducing its new integrated in situ workflow for Zeiss field emission scanning electron microscopes (FE-SEM). When researchers need to link material performance to microstructure, which is essential for developing novel materials in a highly efficient way, they can now extend their Zeiss FE-SEM with an in situ solution for heating and tensile experiments. This allows them to observe materials like metals, alloys, polymers, plastics, composites, and ceramics under heat and tension automatically while plotting stress-strain curves on the fly. They can control all system components from a single PC with a unified software environment that enables unattended automated materials testing for up to 24 hours. Core imaging facilities and materials research labs in academia, government and industry will equally benefit from this new solution.


In situ materials testing in the SEM delivers precise measurement of the dynamic response of microstructures to mechanical load under defined temperature conditions. Thanks to the design of Zeiss Gemini electron optics, the integration of in situ hardware is very straightforward. Materials scientists can easily add information such as local chemical composition or crystallographic orientations using combined analytical techniques (e.g., EDS and EBSD). All Zeiss FE-SEMs can be plugged into the Zeiss ZEN core ecosystem, giving users access to ZEN Connect, ZEN Intellesis, and ZEN’s analytical modules, for example.


Dr Michael Albiez, Head of Zeiss Research Microscopy Solutions, commented: “The ability to quantify material microstructure and bulk mechanical properties in a single automated, user-independent experimental environment provides researchers with the tools necessary to design next generation materials for the future low carbon economy. The in situ lab is not only fully integrated but service and application support are also included. What makes our solution unique is that users can define multiple regions of interest (ROIs) and therefore can be sure to never miss interesting areas of their sample.”


The solution is available for immediate upgrade on existing Zeiss GeminiSEM 360 & 460 and Zeiss Sigma 500 microscopes or can be purchased with new systems.


More information online: ilmt.co/PL/qZaV 57612pr@reply-direct.com


LABMATE UK & IRELAND - SEPTEMBER 2022


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56