38 Air Jet Sieving of Fine Powders
Endecotts’ Air Jet Sizer 200 has been designed for sieving very fine dry particles from 20 microns upwards which require efficient dispersion and deagglomeration via air jet technology. This could be difficult to sieve particles like electrostatic material. It is also the perfect instrument to quickly provide a sieve cut of powdered materials. Most sieving operations on the Air Jet Sizer take only a matter of minutes. Useful functions including the ability to regulate the level of vacuum, and constant or timed operation help to achieve optimum performance. The Air Jet Sizer 200 is easy to use, extremely efficient and provides accurate and reproducible results.
The Premium Air Jet Sieves are specially designed for the use with the Endecotts Air Jet Sizer 200 and other brands. They are available in stainless steel frame and 8” diameter (203 mm) in an extensive range of aperture sizes to ASTM E11 and to ISO 3310-1.
More information online:
ilmt.co/PL/WBEP 48611pr@reply-direct.com
Oligonucleotide Separations with RP Phases
Therapeutic oligos represent an important area of research in the pharmaceutical industry today. These drug candidates are typically 8-50 nucleotides long and contain single-stranded DNA or RNA. Oligonucleotides are typically analysed using ion-pairing chromatography. Oligonucleotides are easily degraded via phosphodiester-cleaving enzymes.
However, with a thiophosphate modified phosphate group, the stability significantly increases. Phosphorothioate modified oligos will have a stereocenter at each modified phosphate group, leading to 2n-1 diastereomers, all with an individual retention time in the chromatography. For a 20-nucleotide long oligo, that’s 524 288 species present. The partial resolution of these species results in peak broadening, further complicating chromatographic separation. To resolve the problem, ion-pairing agents with longer alkyl chains can be used.
In a study of the influence of stationary phase and ion-pairing agent on the separation of oligos, Kromasil Phenyl showed to be a very good choice when separating oligonucleotides in general, exhibiting very sharp peaks, and good selectivity.
More information online:
ilmt.co/PL/XvKy 48275pr@reply-direct.com
IATA Compliant Transport for Streck Cell-free DNA Blood Collection Tubes Streck Cell-Free DNA BCT®
as non-invasive prenatal testing (NIPT) and liquid biopsies.
Available exclusively in the UK from Alpha Laboratories, they contain a unique preservative that stabilises nucleated blood cells and prevents the release of genomic DNA (gDNA).
Blood samples often need to be transported between clinic and laboratory. They are subject to Category B Biological Substances, UN3373 regulation. For transportation, they must be packaged according to the IATA DGR (air transport) or ADR (transport by road) Packing Instructions 650.
Following pressure differential testing performed per IATA UN3373 standards, Cell-Free DNA BCTs have been certified fully 95kPa IATA compliant. This means they can now be paired with the unique SpeciSafe®
packaging solution for convenient transportation. This all-in-one secondary packaging
system combines ultra-absorbent material bonded to a rigid container with built in tube separation. Together with a padded envelope or bag as the outer packaging for road transport, or a rigid outer box for air transport, these mailing packs offer a perfect, compliant solution for transportation of Cell-Free DNA BCTs containing blood samples.
Please visit
www.alphalabs.co.uk for further information.
48196pr@reply-direct.com
CE blood collection tubes allow isolation of high-quality cell-free DNA (cfDNA) for use in a wide range of applications such
New Automated Cell Counter Removes the Need for Slides
DeNovix Inc. announces the launch of the CellDrop Automated Cell Counter. CellDrop is the first instrument to incorporate DeNovix’ patent-pending DirectPipette™ Technology, removing the need for expensive, environmentally damaging plastic slides.
Drawing on technology from the multi award-winning DS-11 Series Spectrophotometer/Fluorometer, CellDrop brings the simple Load, Measure & Wipe Clean functionality of nanovolume spectrophotometers to cell counting. The unique, variable volume counting chamber can be automatically adjusted to the optimum height for each sample, delivering greater accuracy and allowing measurements across the widest range of cell densities, 7x10e2 and 4x10e7 cells without the need for dilution or concentration.
“Our company is focused on developing bio-research products that make workflows easier and address researcher pain points,” stated DeNovix CEO Fred Kielhorn. “Many life scientists spoke of their desire to eliminate the cost and waste associated with automated cell counters, so we developed CellDrop. The instrument not only hits that mark, but it also delivers unrivalled performance and ease of use.”
Combining dual fluorescence and brightfield optics with powerful on board EasyApps®
software enables a range of cell counting, viability and transfection efficiency assays. Instruments come pre-installed with apps for AO/PI, Brightfield, Trypan Blue, GFP and allows the functionality to easily customise methods. The CellDrop is a stand-alone instrument, with a high definition, 7” touchscreen ideal for reviewing live images, data and reports. All instruments contain Wi-Fi, USB, and Ethernet connectivity, allowing users to easily export data via email, network drives, network printers or USB drive.
CellDrop is available in dual fluorescence and brightfield or brightfield only models.
48178pr@reply-direct.com
You can view past issues and find more of the latest news and articles online, at
Labmate-Online.com!
LABMATE UK & IRELAND - APRIL 2019
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