22 Enhancing flow chemistry with CSTR cascade integration
Vapourtec has unveiled a new continuous stirred tank reactor (CSTR) designed to enhance continuous process synthesis, offering compatibility with their renowned flow chemistry systems. This innovative CSTR can be integrated into R-Series and E-Series flow chemistry platforms, significantly expanding their capabilities.
The CSTR cascade system allows for the integration of up to eight reactors within an R-Series flow chemistry system, such as two R4 modules, making it ideal for managing flow reactions that involve both solids and liquids. It operates at pressures of up to 5.0 bar and provides a reactor volume range from 5 ml to 40 ml, with precise temperature control from -10°C to +150°C.
For the entry-level E-Series flow chemistry system, the option to include up to two CSTRs is available, offering enhanced versatility in this system. This easily maintainable system prioritises safety and precision, offering stirring speeds ranging from 100rpm to 1200rpm and featuring a built-in burst disc, with an optional protective screen for added safety.
Additionally, Vapourtec provides the choice of incorporating a photochemical CSTR, which uses LED light sources spanning from 365nm to 700nm. The design of the CSTR is a result of close collaboration with leading flow chemists from both industry and academia.
Dr Manuel Nuño of Vapourtec emphasised the innovative approach, stating: “CSTRs have a well-established presence in chemical synthesis, but our goal was to adapt and optimise them for flow chemistry, ensuring seamless integration with our continuous process systems. The ability to create an eight-reactor cascade configuration significantly improves residence time distribution (RTD) control, allowing for the separation of reaction products from starting materials and precise management of RTDs. With tailored settings for stirring speeds and temperatures in each individual CSTR, this system provides enhanced control and accuracy, leading to more precise outcomes.”
More information online:
ilmt.co/PL/vAVA 61379pr@reply-direct.com
Building blocks for flow chemistry
Uniqsis has developed an extensive range of affordable ‘building block’ modules to which you can simply add your own pumps to create a flow chemistry system.
The Cold Coil II Flow Reactor Module from Uniqsis is designed to provide a flexible, entry-level solution for low temperature flow chemistry applications. Used in conjunction with an external thermoregulation circulator the Cold Coil II can maintain stable temperatures between -78°C and +150°C for extended periods of time. An adapter can be fitted to the module top to support Glass Static Mixer (GSM) chips.
Offering an operating temperature range of ambient to +300°C, the HotCoil reactor heating module provides a versatile solution for your lab to undertake a wide range of flow chemistry reactions. The HotCoil can also be upgraded with a simple adapter to support the use of glass and stainless-steel column reactors for heterogeneous catalysis reaction optimiszation. If you are looking for precise temperature control of flow chemistry reactions in GSM chips – then the HotChip is the heater module for you.
Uniqsis also offer a range of modules allowing you to create a high-performance flow photochemistry system. The Borealis is a high intensity LED lamp unit, available in a range of fixed wavelengths that converts an existing temperature-controlled coil reactor module into a flow reactor for
photochemical applications. The PhotoSyn is a high-power LED light source for continuous flow chemistry scale up applications. Available with a selection of different LED arrays the unit can provide outputs up to 700W from the dedicated programmable power supply. These products give reproducible consistent light penetration, controlled exposure times and precise temperature control resulting in higher yields and improved selectivity.
More information online:
ilmt.co/PL/2X9J 61532pr@reply-direct.com
Innovative water purification for the modern laboratory
Established in 1997, Hydrolab is a leading Polish manufacturer specialising in the design and delivery of state-of-the-art water purification systems tailored for laboratory purposes. With over 25 years of experience, the company has been at the forefront of introducing cutting-edge water purification technologies, including mechanical filtration, adsorption, iron removal, softening, and various membrane technologies (such as reverse osmosis, microfiltration, nanofiltration, ultrafiltration). Hydrolab also incorporates 185nm and 254nm UV radiation and deionisation into its systems.
Hydrolab offers a diverse portfolio of over a hundred water purification systems. Drawing upon years of expertise and research, the company has developed three distinct series of demineralisers: TECHNICAL, HLP, and SPRING. These series provide ideal solutions that meet the stringent requirements of modern laboratories for ultrapure water supply. In addition to the core offerings, Hydrolab has introduced unique and innovative solutions, expanding the range to include the ULTRA, R, and TECHNICAL PLUS series. The product line extends to industrial systems, such as SPRING and TECHNICAL. These demineralisers find wide applications in analytical laboratories, as well as in sectors like pharmaceuticals, chemicals, electronics, and the food industry, among others. The equipment is also popular in settings such as dental clinics and beauty salons.
Beyond equipment supply, Hydrolab offers a comprehensive array of services to ensure the delivery of the highest quality water for laboratories. The company provides guidance and support, from initial planning to installation, complete with IQ, OQ, and PQ documentation. Notably, Hydrolab maintains ISO 9001:2015 certification, covering quality management, design, production, and maintenance of water purification systems. This certification underscores the company’s commitment to upholding the highest standards in both its products and services.
More information online:
ilmt.co/PL/mVLw 61381pr@reply-direct.com
Innovative pH measurement method for particle sizing
Fritsch has pioneered a ground-breaking method to measure the pH value of dispersion liquids directly within the measuring unit. The newly integrated pH sensor module in the dispersion bath is connected to the Laser Particle Sizer, enabling continuous pH monitoring during measurements and automatic data transfer to the software for documentation.
This patented approach proves significantly more effective in handling fluctuations compared to the zeta potential method. It offers substantial advantages, particularly in research and development contexts. The pH value holds broader significance, especially in nano-suspension measurements, providing valuable insights into how chemically inert materials react to varying environmental conditions. When measurement curves are unstable, the pH value aids in stabilisation and interpretation. Moreover, Fritsch’s newly introduced patented pH measurement method allows for precise observation, facilitating the detection of agglomeration or aggregation.
Fritsch Particle Sizers offer state-of-the-art particle sizing solutions, catering to both production and quality control, as well as research and development applications, and manufacturing process control. The Fritsch A-22 NeXT Nano, a Laser Particle Sizer, excels in accuracy and sensitivity, covering a wide measuring range from 0.01 to 3800 μm. Additionally, a Micro version offers an economical alternative with a measuring range from 0.5 to 1500 μm. Both models feature a single laser and numerous patented features to ensure maximum durability and minimal maintenance.
These instruments are designed for easy installation through plug-and-play functionality, tool-free cleaning with simple steps, and come with high-performance software, meeting 21 CFR Part 11 requirements. Fritsch Laser Particle Sizers ANALYSETTE 22 NeXT adhere to a smart, modular concept, allowing customers to purchase only the necessary components and scale their sizing capabilities as needed.
More information online:
ilmt.co/PL/VeG3 and
ilmt.co/PL/8Nev 61297pr@reply-direct.com
LAB ASIA - FEBRUARY 2024
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