Mass Spectrometry & Spectroscopy 9 Putting NMR spectroscopy at the heart of the analytical chemistry lab
Nuclear Magnetic Resonance (NMR) is a widely used technique in analytical chemistry laboratories. Due to its non-invasive and non-destructive nature, it’s perfect for in situ reaction monitoring or hyphenation with other techniques in a QA/QC lab. Benchtop NMR has a number of advantages over traditional high field NMR. It is smaller and more compact so can be used right beside the bench, or even inside a fume hood. This is in contrast to high field instruments that often require their own room to operate in and a continuous supply of very expensive cryogen. Cryogen-free benchtop NMR however, relies on permanent magnets and can be easily transported between labs or to manufacturing lines. Recently, Oxford Instruments unique broadband NMR spectroscopy with capability to analyse nearly all NMR active chemical nuclei, has significantly increased the number of applications that can be addressed by benchtop NMR across education, academia, and industry. These include structural identification, reaction monitoring, and flow chemistry to name a few.
Download this article to discover: • The savings that can be made by switching to benchtop NMR • How benchtop NMR can solve problems in education, academia and industry • How broadband benchtop NMR enables maximum flexibility for instrument location and detection of X nuclei More information online:
ilmt.co/PL/qn4l
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Using Benchtop NMR in drug development laboratories
Are you interested in gaining a greater understanding of your candidate molecules or reaction intermediates?
NMR spectroscopy is one of the most powerful tools for the structural elucidation of an unknown chemical compound, and the structural confirmation of known compounds. During the later stages of the drug development and manufacturing processes benchtop NMR, can be used to investigate a range of samples from quality control of stock chemicals, to identifying components in complex reaction mixtures.
In this application note, the X-Pulse broadband benchtop NMR Spectrometer from Oxford Instruments is used to perform a full structural elucidation of the anti-inflammatory drug, ibuprofen. It explains how using one- and two- dimensional proton and carbon-13 spectra, the molecule is identified as the monocarboxylic acid, ibuprofen.
Read the application note: Structural Elucidation by Benchtop NMR Spectroscopy: Ibuprofen.
More information online:
ilmt.co/PL/oBeo and
ilmt.co/PL/MMAd
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