52 February / March 2020 New Semi-Preparative SFC System Meets Pharmaceutical Industry Purification Standards
Shimadzu Corporation, in partnership with the Enabling Technologies Consortium™ (ETC), announces the release of the Nexera Preparative Supercritical Fluid Chromatography System, ‘Nexera UC Prep’. This next- generation prep SFC system provides the pharmaceutical industry with reliable high-performance semi-prep purification.
The Nexera UC Prep is part of Shimadzu Nexera UC platform, which accommodates a wide variety of analyses and purifications. The platform is based around the Nexera ultra high-performance liquid chromatograph. Each Nexera UC Prep is configurable to user specifications in order to optimally perform the desired purification function including chiral or achiral purifications, single injections, stacked injections, and fraction collections from several microliters to litres.
This complete SFC solution reduces the need for costly and hazardous solvents used in normal phase prep LC, while shortening purification run time and dry down time. Innovative technologies include a flexible format combination injector/fraction collector, CO2 pump with integrated chiller that requires less lab space and allows for benchtop use, a novel gas-liquid separator design, ‘LotusStream’, to ensure high recovery and low carryover, and easy-to-use preparative software, ‘Prep Solution’, to streamline operations.
Importantly, the newly designed gas-liquid separator, ‘LotusStream separator’, realises a higher recovery ratio and lower carryover than earlier SFC systems. Moreover, the elegant design of LotusStream separator reduces the total size of the recovery system and allows for easy rinsing compared to earlier cyclone-style or centrifugal type gas-liquid separating systems.
“The Nexera UC Prep system is an improved purification instrumentation that meets the specifications and requirements from SFC users across the pharmaceutical industry,” said Mirlinda Biba, PhD, Principal Scientist, Merck & Co Inc, and ETC lead for this project. “This new generation system provides improved hardware and software features that answer the pharmaceutical industry’s demand for an efficient and robust prep SFC system.”
“Working with the Enabling Technologies Consortium, and hearing the voice of the pharmaceutical industry, has been an incredibly valuable learning experience for us at Shimadzu,” said Patrick Fromal, VP Sales, Shimadzu Scientific Instruments.
ETC is a forum for pharmaceutical and biotechnology companies to discuss ideas, share information and collaborate on the development of new enabling technologies.
More information online:
ilmt.co/PL/QDQW New C18 Cannabinoid HPLC Columns
The analysis of cannabinoid samples, to perform complete profiling of the various cannabis and hemp strains and more accurate potency testing, is becoming more essential. There are at least 100 identified cannabinoids that have been isolated from cannabis sativa. These minor cannabinoids can possibly interfere with the chromatography of the five most common cannabinoids: tetrahydrocannabinol (THC), delta-9- tetrahydrocannabinolic acid A (THCA), cannabidiol (CBD), cannabidiolic acid (CBDA), and cannabinol (CBN). ES Industries Inc have developed a new C18 column - Epic C18 Cannabinoid to fully
resolve the 11 major and most frequently observed minor cannabinoids using commercial standards. The baseline separation achieved with the Epic C18 Cannabinoid column ensures positive identification and accurate quantitation for the cannabinoids of interest. Epic C18 Cannabinoid is based on the robust Epic bonding chemistry developed by ES Industries. The superior performance of Epic C18 Cannabinoid is a product of high density bonding which has been achieved through refinements in the processes and catalyst development. High bonding density is one of the most important factors in producing a robust stationary phase and robust HPLC column. The eleven component cannabinoid analysis is achieved with Epic C18 Cannabinoid using a simple isocratic mobile phase which is more easily transferable between instruments/laboratories, compared to more complex methods that incorporate atypical mobile phase gradients or additives.
More information online:
ilmt.co/PL/zyje Reduced Surface Activity
Glass Autosampler Vials RSA Glass™ autosampler vials and inserts have reduced surface activity for basic compounds. This is due to the elimination of virtually all silanols (hydroxyl groups) that can have deleterious effects on your analytes and sample solutions. These vials are not manufactured with coatings; but have significantly reduced silanols and surface ions on the glass surface
normally produced during the manufacturing process. This lack of surface ions makes them an excellent choice for HPLC, LCMS, GC and GCMS applications when quantitation, reliability and accuracy are important.
More information online:
ilmt.co/PL/Z349
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