Microscopy, Microtechnology & Image Analysis
Modular Upright Research Microscopes for Bioscience and
Medical Research Innovative LED Blue Light Transilluminator
Syngene, a manufacturer of image analysis solutions, today introduced the UltraBright-LED transilluminator, a new generation of blue light transilluminator designed for safely imaging fluorescently labelled gels (up to 20cm x 16cm) on the bench or inside Syngene G:BOX imaging systems. The UltraBright-LED uses two high intensity LED arrays which produce uniform, bright excitation at 470nm, and can illuminate dyes that excite at 420 to 480nm. Therefore, the system is suitable for visualising small amounts of Ethidium Bromide and non-toxic DNA stains including Syngene’s new UltraSafe Blue™ dye, SYBR Safe and GelGreen, as well as protein stains such as SYPRO Ruby and Pro-Q Diamond. Since the UltraBright-LED uses blue light, researchers imaging non-toxic stains can use the system directly on the bench and as it is compact and light weight it takes up very little space and is easy to move.
The UltraBright-LED features a special filter in its lid which enhances band contrast and provides optimum viewing conditions. The transilluminator has been designed to easily slide in and out of any Syngene G:BOX imaging system, making the UltraBright-LED ideal for visualising faint bands, allowing precise band cutting and production of high quality images for analysis and publication.
Laura Sullivan, Syngene’s Divisional Manager stated: “Blue light transilluminators are an alternative to UV when scientists work with non-toxic fluorescent dyes. The advantage of using blue light is that it is a “safe” light source which can be used on the bench, as it is not as harmful as UV and does not photo-nick DNA samples.”
The Nikon evolution in upright biological microscopes has advanced with the new Eclipse Ni series. Using core technology from Nikon’s renowned Eclipse Ti inverted research microscope, the Eclipse Ni series offers multi- mode system expandability to meet the imaging needs of bioscience and medical research on one platform. The new Ni range also provides superior optical performance with new CFI Plan Apochromat Lambda series objectives, and the flexibility of assisted observation by motorisation. The range comprises the fully motorised Eclipse Ni-E flagship model with focusing nosepiece or focusing stage options, and the manual Eclipse Ni-U with motorisation upgrade capability.
Nikon’s highly acclaimed proprietary stratum structure in the Ni series opens up a vast range of imaging possibilities that can be upgraded at any time. Both models support research into the reactions and changes of stimulated cells with a newly developed photoactivation unit, a first for upright microscopes. The Eclipse Ni-E is also configurable for multiphoton imaging, as well as offering the option of fixed-stage configurations to meet the demands of experiments such as in vivo imaging for cardio vascular and neuroscience research applications.
The new Eclipse Ni microscopes use the latest version 4.0 release of NIS-Elements software enabling microscope, camera and confocal control, thereby removing the need for a laboratory to rely on separate software. Image acquisition and analysis is improved with over 100 new functions. Superior optical performance is ensured through Nikon’s new CFI Plan Apochromat Lambda series objectives with Nano Crystal Coat technology. Transmission and chromatic aberration correction have been improved throughout the wide range of visible to near IR wavelengths (950nm), providing bright, high- contrast, high signal-to-noise ratio and multi-colour fluorescence images with no perceivable focus shift when used with any wavelength.
A comprehensive range of high speed, motorised accessories, specifically configured according to application, augment the improved features to meet all research requirements. Simple one-touch control buttons to the side of the microscope combine with improved ergonomic design for speed, ease of access and comfort for motorised focusing. The higher speeds of the motorised excitation and barrier filter wheel and the motorised shutter enable fast wavelength changes, reducing photobleaching of the specimen. A new Nikon motorised stage option is effective for applications that require highly accurate positioning, capture move and repeat experiments or image tiles stitching. Intelligently located electrical connections on each unit also minimise the number of connection cables for seamless and tidy integration.
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Laura continued, “We are delighted to introduce the UltraBright-LED blue light transilluminator as it complements our UltraSlim-LED transilluminator for use in Syngene’s In:Genius3 and U:Genius3 gel doc systems. The UltraBright-LED transilluminator when used in combination with a G:BOX system, is an excellent tool for researchers looking to generate outstanding gel images without compromising their DNA quality or their safety.”
Supporting Cancer Drug Delivery Safety The new FlowCAM®
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PV Series imaging particle analysis system from laboratory instrumentation
manufacturer Fluid Imaging Technologies automatically takes high-resolution, digital images of individual particles of encapsulated Paclitaxel to detect the presence of aggregates in the cancer treatment formulation and permit testing and assessment of drug delivery carriers and methods such as intravenous drip, emulsion, liposome and microsphere. Invaluable for documenting the safety of Paclitaxel in parenterals and for monitoring particulates in coatings on stents, catheters and other medical devices, the FlowCAM reveals both the Paclitaxel and its carrier in full colour and measures each particle based on the actual size and shape as imaged. The particles are characterised in real-time with up to 32 different parameters including advanced morphological properties such as perimeter, roughness, elongation and compactness, along with a host of traditional properties such as size, length, aspect ratio and ESD.
Detecting thousands of particles in a sample in less than a minute, the FlowCAM PV-40 and FlowCAM PV-100 Particle Vision series particle analysers save the images and corresponding data with a cGMP date and time stamp as tiff or jpeg files for easy review and emailing to colleagues. The FlowCAM biopharmaceutical instrumentation excels at detecting particles ranging from 2µm to 800µm in size even with samples as small as .1ml. Paclitaxel is also sold as Taxol, Abraxane® and Praxel.
, Apo-Paclitaxel® , Aclixel, Asotax, Bristaxol, Bryoxet Circle no. 595 ELISA Microplates for Diagnostic and Immunological Research
Porvair Sciences has announced a new range of high performance 96- well ELISA microplates for diagnostic and immunological research applications.
Available with a choice of surface binding coatings an optimised Porvair ELISA microplate can be supplied for most applications.
Manufactured from virgin USP Class VI crystal polystyrene - Porvair ELISA plates ensure excellent results with microplate readers. Produced as a one-piece moulding - Porvair ELISA plates have an exceptionally flat base with good clarity across the well bottom and even base thickness ensuring high accuracy and precision when making well-to-well measurements. The robust design, highly polished tools and attention to material quality make these new inexpensive ELISA plates a first choice for many laboratories worldwide.
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