MeetingPreview
Our second plenary speaker will be Dr. Richard Henderson
of the Medical Research Council Laboratory of Molecular Biology (MRC LMB), Cambridge, UK. Dr. Henderson was awarded the Nobel Prize in Chemistry 2017, together with Jacques Dubochet and Joachim Frank, for “Developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution.” He will present a talk titled “Single particle cryoEM: potential for further improvement.” Dr. Henderson developed TEM into a tool for the direct determination of the structure of proteins, and he applied it most nota- bly to two-dimensional (2D) crystals of the purple light-harvesting protein, bacteriorhodopsin. Images and electron diffraction patterns of many 2D crys- tals of bacteriorhodopsin from multiple angles were acquired using low-dose electron exposures, and combined to generate a 3D image of the protein. He continued to refine this technique over many years until he produced images at similar resolutions as those obtained from X-ray diffrac- tion. Later, Dr. Henderson turned his attention to the develop- ment and improvement of methods of high-resolution electron cryo-microscopy and single particle structure determination. With colleagues, he advanced these techniques for exploring high-resolution ultrastructure of membrane proteins, protein complexes, and other non-crystalline biomolecules in solution. During this journey, Dr. Henderson made critical contributions to many single-particle electron microscopy approaches, includ- ing pioneering the development of direct electron detectors. Dr. Henderson was presented with MSA’s Distinguished Biologi- cal Scientist Award in 2005. As usual, M&M 2019 will present a great variety of sym-
Dr. Richard Henderson
posia topics in analytical, life, and physical sciences. Tis year, we have a special symposium: “Cryo-EM – from Physics to Cell Biology: Honoring the Remarkable Legacy of Ken Downing.” It will showcase the late Dr. Downing’s work in single-particle cryo-EM, cryo-electron tomography, and the microscopy meth- ods he used for his seminal discoveries. Dr. Downing, MSA Fellow and former MSA president, was enormously influential in the field of electron microscopy. His scientific accomplishments span an amazing range of widely recognized techniques and methods. Work in his laboratory led to the first high-resolution struc- ture of tubulin using electron crys- tallography, and he made important contributions to the current “resolution revolution” in single-particle cryo-EM. Perhaps even more importantly, Ken Downing was a wonderful mentor to the next generation of scientists. Preceding the M&M 2019 technical program, we will have
Dr. Kenneth Downing (1945–2018)
two pre-meeting congresses. First, “NexTEM: Next-generation Transmission Electron Microscopy – Beyond Current Limits of Resolution, Environments, and Data Analysis” will include
2019 January •
www.microscopy-today.com
presentations and a discussion forum about integration of advanced and emerging instrumentation, as well as approaches to examine nanoscale systems with high spatial resolution and chemical sensitivity, novel in situ and operando methods to study the dynamics of complex materials systems, and data analysis tools and machine learning approaches. Secondly, the “Tird Annual Pre-Meeting Congress for Students, Post-Docs, and Early-Career Professionals in Microscopy and Microanalysis,” organized by the MSA Student Council, will provide a forum to share research and data in an engaging, non-intimidating, and interactive setting. Tis event provides professional network- ing among fellow young microscopists and career development mentoring from recent graduates. Te Friday evening social, Sat- urday lunch, and evening banquet are included with registration. Education and training are important components
of the M&M technical program each year, and 2019 is no exception. Six Sunday short courses on material science, biol- ogy, and data analysis will be presented. Additional oppor- tunities are available in tutorials in biology and physical sciences during the meeting week. This year, the tutorials will cover the cutting-edge subjects of machine learning, electron ptychography, electron optics for cryoEM, and the computational toolbox for cryoEM, to name just a few. The Technologists’ Forum will present invited experts in two roundtable discussions. In “Technical Careers in Micros- copy – For the Love of Microscopy,” a panel of technolo- gists, including early- and late-career technologists from academia and industry, will discuss their careers in micros- copy and how they evolved through the years. Learn how to become a Certified Electron Microscopy Technologist (CEMT) and what it can do for your career. Another round- table discussion will focus on “Utilization of the National NIH funded Cryo-EM Centers: Transformative High Res- olution Cryo-Electron Microscopy,” with scientists from three national cryo-EM centers discussing various aspects of cryo-EM techniques. Finally, our popular microscopy outreach workshop “Pro-
jectMICRO” will be in the MegaBooth all week. See different microscope systems and learning stations for use in the class- room, peruse the books suitable for elementary school age children, and share your experiences of how you have fun with microscopy outreach. For a complete description of the technical program and
educational opportunities, please go to http://www.micros-
copy.org/MandM/2019. Te Call for Papers and other aspects of the program and the meeting are provided under the “Scientific Program” button. Te Executive Program Committee welcomes you to Port-
land for an excellent and compelling Microscopy & Micro- analysis 2019. Catch up with old friends and make new ones! Look for opportunities to attend society business meetings and socials during the week. On behalf of MSA, MAS, IFES, in cooperation with over a hundred symposia organizers and countless volunteers, we look forward to seeing you in Port- land this August!
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