Micrographs with Cloud Computing
Figure 1: Bioavailability of active pharmaceutical ingredients in a biologically friendly amorphous state studied using DigiM I2S cloud image management and AI image segmentation [3]. (a), (b) and (c) are cross-section images extracted from 3D X-ray MicroCT tomographs of three selected samples: D10 (no drug), D11 (low drug crystallinity), and D12 (high drug crystallinity). (d) Cross section of D12 at higher magnification. (e) Same image overlaid with AI-based segmentation of four phases: blue – copovidone polymer; red – amorphous drug; yellow – crystalline drug; black – pore. (f) Pore size distributions from the three samples: D10 (orange), D11 (blue), and D12 (green). (g) Crystalline drug particle size distributions for D11 (orange) and D12 (blue). Note curves in (f) and (g) are for data selected, from large numbers of measurements, for clearer comparisons. The jagged curve for D11 is due to a smaller number of particles measured.
(for example, electrical conductivity using Ohm’s law and ther- mal conductivity using Fourier’s law), and complex properties with multiple solid and fluid phases under variable pressure, temperature, and flow conditions. Image data and their analysis results are integrated with
a database, which supports searching, indexing, logging, and tracking. Te user retains access to all data at his or her fingertips all the time. Powerful web-based visualization soſtware permits the user to share, communicate, and keep records on his data. Te DigiM I2S soſtware package also supports multi-user collaboration. It can operate either as a remote cloud, or as an on-premise private cloud, to satisfy
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a variety of needs in data amount, data confidentiality, and data transfer speed. Cost advantages. Cloud computing is convenient and
cost-effective. It reduces the upfront cost for the user of soſt- ware, hardware, and IT to zero. Current commercial and open-source solutions tie functions with usage, and the pre- mium usage fee is charged regardless how much a user uses a soſtware. With a cloud computing platform such as DigiM I2S, a heavy user can subscribe at a premium level, which sup- ports his interactions with large quantities of data and large computation demands. On the other hand, a light user will subscribe at a standard level and pay on-the-fly only when
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