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as in animals, PQQ increases antioxidant potential, positively impacts inflammatory markers, and influences energy-related metabolism and neurologic functions.


CoQ10 (As Ubiquinol): This antioxi-


dant, which Stephen Sinatra, MD, FACC, calls “the spark of life,” is critical to the gen- eration of cellular energy (ATP) and enables oxygen utilization. It is highly concentrated in organs with higher energy requirements (especially those that manufacture it, the heart, liver, kidneys, and pancreas), but is also found in every cell of the body. In his book entitled The Great Cholesterol Myth: Why Lowering Your Cholesterol Won’t Prevent Heart Disease, Dr. Sinatra recom- mends at least 100mg twice per day, espe- cially for every patient taking a statin drug. Ideally, ubiquinol (the active, reduced form that is absorbed up to eight times better than regular CoQ10) should be taken with a fat, only in the morning and afternoon.


R-Lipoic Acid: This potent form of wa-


ter-and-fat-soluble alpha lipoic acid: (1) is critical to mitochondrial function because it is essential to the extraction of energy from food; (2) counteracts mitochondrial and other cellular free radicals that cause oxida- tive stress (thus protecting especially brain, liver, and heart cells); and (3) recycles other antioxidants like glutathione and vitamins C and E. There is evidence that it can reduce age-promoting protein glycation damage.


L-Taurine: This amino acid regulates the enzymes that harvest energy from food. It is highly concentrated within mitochon- dria, particularly in those of the heart, muscles, brain, and retina. The energy crisis that results from its depletion in mammals


causes accelerated aging. Taurine supple- mentation can reduce oxidative stress, maintain/restore mitochondrial function in aging cells, and even help preserve cogni- tion and memory.


Other Aging-Optimization Nutrients


Vitamin D: (1) inhibits inflammatory response; (2) deficiency is linked to cogni- tive impairment; (3) reduces mortality risk by 30% in patients with cardiovascular disease who have a normal intake (heart- protective blood values should be 42-100 nmol/l); (3) higher serum concentrations are associated with longer telomere length of white blood cells.


Fish Oil (Omega-3 Essential Fatty


Acids): As discussed in Part 1 of this article, telomere length is tied to longevity. Telo- meres progressively shorten as part of the aging process, causing organs to atrophy and brain cells to die. In 2011, JAMA re- ported a cardiac study that demonstrated “a potentially new link between Omega-3 fatty acids and the aging process.” Researchers found that patients with high levels of ome- ga-3 fatty acids in their white blood cells experienced significantly less shortening of telomeres over five years, as compared with patients with lower omega-3 levels.


Nicotinamide Riboside (NR): This cell-


regenerating nutrient is a form of vitamin B3 that efficiently increases NAD+ (present in every human cell; contributes to regulat- ing cell aging, DNA repair, and the transfer of energy from fatty acids and glucose to the mitochondria). As a dietary supplement, NR has the potential to improve meta- bolic and age-related disorders (including high-fat-diet-induced obesity), and tissue


damage, characterized by mitochondrial dysfunction.


Benfotiamine (Fat-Soluble B1): Accord- ing to lab studies, this B vitamin functions as an antioxidant and can prevent glyca- tion. Human studies have proven that it can help prevent the damage resulting from glycation, especially in diabetics.


Pyridoxal 5’-phosphate (P5P/Coen-


zyme B6): This active form of B6 inhibits the glycation of fats and proteins.


Probiotics: While scientists have stud- ied probiotics (“good” bacteria similar to those in the human gut) extensively, much about their function and benefits remains unknown, and their effectiveness varies among strains and products (particularly because not all successfully adhere to gut cells to populate the intestines). Studies have proven, however, that taking probiot- ics can improve gut function and other as- pects of human health, including immunity.


While inclusion of all of the above nu- trients in a supplements regimen would be excessive, including some, along with diet modification to reduce inflammation and free radicals, and other lifestyle changes, certainly makes sense for anyone seeking to live healthier and longer.


Submitted by J. Erika Dworkin, Board Certified in Holistic Nutrition®, Nutrition Consultant and Owner of the Manchester Parkade Health Shoppe (860.646.8178), 378 Middle Turnpike West, Manchester, CT, (www.cthealthshop.com), nutrition special- ists trusted since 1956. Erika is available to speak to groups. All statements in this ar- ticle are research-based and references are available upon request. See ad on page 7.


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36 Natural Nutmeg - October 2018


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