Curcumin (as Theracurmin®/Meriva®/
BCM95®): Recent studies have demon- strated that curcumin from turmeric, and its metabolite tetrahydrocurcumin (THC), increase mean lifespan of at least three organisms (the nematode roundworm, fruit fl y Drosophila, and mouse). Their positive effects are thought likely to arise from the benefi cial regulation of oxidative stress responses and age-related genes. These studies provide a solid basis for both future human clinical trials and nutritional inter- vention in aging and age-associated human disorders.
Flavonoids: This class of polyphenols/ antioxidants is principally responsible for the colors of fruits and fl owers, and protects plants against environmental stress. Flavonoids enable the human body to combat infl ammation, allergens, viruses, and carcinogens. The best supplements options include those high in oligomeric proanthocyanadins (OPCs), such as grape- seed extract, pycnogenol, green tea extract, trans-resveratrol (from Japanese knotweed or red wine), and ginkgo biloba extract (GBE-24% standardized ).
Selenium (as L-Selenomethionine):
This essential trace mineral affects all ele- ments of immunity, including the develop- ment and expression of all white blood cells. Its availability in the body regulates the activity of glutathione peroxidase. Stud- ies have proven its ability to increase thy- mus gland function, the activity of natural killer cells, and destruction of tumor cells.
Vitamin C (Lyposomal/EsterC): Studies
have established vitamin C as critical to the suppression of oxidative stress that protects proteins and fats from free radical damage. This process increases the life span of im- mune cells, reduces infection-related cellu- lar damage, and may also help prevent the onset of infections. Maintaining adequate plasma levels of vitamin C is also associ- ated with weight loss and healthy weight maintenance, well-established as support- ive of longer health and life spans.
Mitochondrial Supporters
PQQ (Pyrroloquinoline quinine): Although studied to a limited degree, this nutrient has been shown to: (1) activate genes that promote formation of new mitochondria (cellular powerhouses); (2) increase cellular energy; and (3) interact with genes that directly impact mitochon- drial health. These genes support healthy body weight, normal fat and sugar metabo- lism, and youthful cellular proliferation. A small human study in 2013 confi rmed that,
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