Drug Discovery World Winter12

Stem Cells

References 1 Hanna, JH, Saha, K and Jaenisch, R. Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell, 2010. 143(4): p. 508-25. 2 Alison, MR and Islam, S. Attributes of adult stem cells. J Pathol, 2009. 217(2): p. 144-60. 3 Copelan, EA. Hematopoietic stem-cell transplantation. N Engl J Med, 2006. 354(17): p. 1813-26. 4 Czechowicz, A and Weissman, IL. Purified hematopoietic stem cell transplantation: the next generation of blood and immune replacement. Immunol Allergy Clin North Am, 2010. 30(2): p. 159-71. 5 Stroemer, P et al. The neural stem cell line CTX0E03 promotes behavioral recovery and endogenous neurogenesis after experimental stroke in a dose-dependent fashion. Neurorehabil Neural Repair, 2009. 23(9): p. 895-909. 6 Itzhaki, I et al. Modelling the long QT syndrome with induced pluripotent stem cells. Nature, 2011. 471(7337): p. 225-9. 7 McNeish, J et al. High-throughput screening in embryonic stem cell-derived neurons identifies potentiators of alpha-amino-3-hydroxyl-5- methyl-4-isoxazolepropionate-type glutamate receptors. J Biol Chem, 2010. 285(22): p. 17209-17. 8 Zhang, J et al. Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res, 2009. 104(4): p. e30-41. 9 Rubin, LL and Haston, KM. Stem cell biology and drug discovery. BMC Biol, 2011. 9: p. 42. 10 Smith, AG. Embryo-derived stem cells: of mice and men. Annu Rev Cell Dev Biol, 2001. 17: p. 435-62. 11 Lister, R et al. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature, 2011. 471(7336): p. 68-73. 12 Hussein, SM et al. Copy number variation and selection during reprogramming to pluripotency. Nature, 2011. 471(7336): p. 58-62.

13 Gore, A et al. Somatic coding mutations in human induced pluripotent stem cells. Nature, 2011. 471(7336): p. 63-7. 14 Merkle, FT and Alvarez-Buylla, A. Neural stem cells in mammalian development. Curr Opin Cell Biol, 2006. 18(6): p. 704-9. 15 Conti, L et al. Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. PLoS Biol, 2005. 3(9): p. e283. 16 Li, W et al. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci U S A, 2011. 108(20): p. 8299-304. 17 D’Amour, KA et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol, 2006. 24(11): p. 1392-401. 18 Daley, WP, Peters, SB and Larsen, M. Extracellular matrix dynamics in development and regenerative medicine. J Cell Sci, 2008. 121(Pt 3): p. 255-64. 19 Jiang, J et al. Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells, 2007. 25(8): p. 1940-53. 20YC. Use of Combinatorial Screening to Discover Protocols That Effectively Direct the Differentiation of Stem Cells Stem Cell Research and Therapeutics in Stem Cell Research and Therapeutics, D.O.C. Y. Shi, Editor 2008, Springer Science + Business Media. p. 227-250. 21Wu, X et al. Small molecules that induce cardiomyogenesis in embryonic stem cells. J Am Chem Soc, 2004. 126(6): p. 1590-1. 22 Barbaric, I et al. Novel regulators of stem cell fates identified by a multivariate phenotype screen of small compounds on human embryonic stem cell colonies. Stem Cell Res, 2010. 5(2): p. 104-19. 23 Chen, S et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol, 2009. 5(4): p. 258-65.

24 Desbordes, SC et al. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell, 2008. 2(6): p. 602-12. 25Wang, D et al. A pure population of lung alveolar epithelial type II cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A, 2007. 104(11): p. 4449-54. 26 Elliott, DA et al. NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat Methods, 2011. 8(12): p. 1037-40. 27 Li, M et al. Generation of purified neural precursors from embryonic stem cells by lineage selection. Curr Biol, 1998. 8(17): p. 971-4. 28 Choi, CK, Breckenridge, MT and Chen, CS. Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering. Trends Cell Biol, 2010. 20(12): p. 705-14. 29 Kobel, S and Lutolf, M. High-throughput methods to define complex stem cell niches. Biotechniques, 2010. 48(4): p. ix-xxii. 30 Flaim, CJ et al. Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells Dev, 2008. 17(1): p. 29-39. 31 Engler, AJ et al. Matrix elasticity directs stem cell lineage specification. Cell, 2006. 126(4): p. 677-89. 32Yang, MT et al. Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity. Nat Protoc, 2011. 6(2): p. 187-213. 33 Fernandes, TG et al. Three-dimensional cell culture microarray for high-throughput studies of stem cell fate. Biotechnol Bioeng, 2010. 106(1): p. 106-18. 34Wylie, RG et al. Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels. Nat Mater, 2011. 10(10): p. 799-806.

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Drug Discovery World Winter 2011/12

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