Automation
without reprogramming. Much like a standard pipette, the flexibility of Roboline enables pipet- ting of any combination of columns, rows, single wells or entire plates. The housing is easy to clean and the closed environment protects samples from contamination. A removable tray makes unloading and loading possible even when the robot is work- ing on another task. Roboline’s size (25.4lb, the smallest on the market) and low noise level (60dB) make it a true bench-top instrument. Roboline is developed by Sartorius Biohit which has many years of experience in liquid handling and the man- ufacturing of electronic pipettes (Figure 24).
Figure 24: Biohit Roboline pipetting automate is developed by Sartorius Biohit
easiness and user-friendliness of Roboline is based on several facts. The graphical user interface can be learned in just 15 minutes and the simple drag-and- drop function helps you modify your protocol. Additional features, such as the standard curve wizard, ease programming. The software has a simulator check to eliminate human errors and the unit uses conductive tips to secure liquid transfer. You can save your application and use it again
The new HP D300 Digital Dispenser is an auto- mated benchtop instrument used to generate dose response curves for the pharmaceutical research sector. Available exclusively through Tecan, (
www.tecan.com/digitaltitration) this innovative device can cut titration times from hours or days to just minutes. The HP D300 offers the unique flex- ibility to walk up and easily perform titrations at the bench. It provides fast and reliable perform- ance across a large dynamic range, eliminating the need for slow, error-prone and wasteful dilution steps. Using disposable dispense heads to avoid cross-contamination, the instrument offers com- plete freedom for non-contact dispensing from 13pL to 5µL, delivering any dose to any well in 96 and 384 plate formats and virtually eliminating waste of valuable compounds. The HP D300 soft- ware is simple, yet powerful enabling practically anyone in the lab to set up classic or complex drug titrations with only minutes of training. Drug-drug interaction studies (2D) are difficult and time con- suming to prepare using conventional methods, but are set up in minutes using the HP D300. Randomisation of the samples within a plate is also accomplished with the click of a button, reducing edge effect bias in cell-based assays. The HP D300 offers a solution to address the most challenging experiments encountered in the lab. The pharma- ceutical industry is recognising a need for change, and there is a growing trend towards benchtop automation solutions. New technologies such as Direct Digital Dispensing can offer fresh solutions to entrenched challenges, helping to improve pro- ductivity and accelerate the discovery of better drugs. The HP D300 Digital Dispenser is available now for delivery in Europe and North America (Figure 25).
Figure 25: Benchtop convenience for your titration experiments with the HP D300 Digital Dispenser from Tecan
40
The Thermo Scientific (
www.thermo.com) Orbitor BenchTrak is a complete modular and customisable automation solution that incorporates ‘click-in’
Drug Discovery World Winter 2011/12
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