48 May / June 2016 Alternatives to Volumetric Solution Preparation


The integrity of HPLC analysis is dramatically affected by the composition of the solutions used; a slight error can result in misidentification of sample components. Design Scientific’s instruments excel in preparing routine solutions gravimetrically.


SoluPrep™ automatically prepares samples with exceptional accuracy for LC, GC, standards and spectroscopy. Sample sizes range 5mL to 250mL. The solvent delivery rate is 100 mL/minute.


PhasePrep™ is designed to prepare large batch routine solutions for HPLC mobile phases, titrations, extractions and internal standards. At 500mL/minute, PhasePrep quickly and accurately prepares solutions ranging from 50mL to up to 8L.


SoluPrep and PhasePrep eliminate volumetric glassware, user-to-user variation and inaccuracies related to temperature. A label is also printed to document the preparation. This minimises the cost of re-works, non-conformance investigations and the costly delays that could result in not shipping finished product. Both instruments offer a full GMP Validation Package.


Contact Julie DeCook, Marketing Communications Director & Office Manager, www.designscientific.com, Tel: 1616-585-5225.


New Conductivity and pH Monitor Works with Virtually Any Chromatography System


Gilson has expanded its chromatography product line with the launch of the VERITY® 1810


Conductivity and pH Monitor, an easy-to-use, compact device that can be integrated with virtually any chromatography system.


Users simply plug the conductivity flow cell of the monitor into the fluid path and power up the monitor by connecting to a PC via the USB cable. From there, the system runs itself, drawing on Gilson’s established automation technology to monitor gradient formation. Researchers can record data from the monitor either through TRILUTION®


LC, Gilson’s chromatography


software, or through analogue output to a third-party device, which allows the monitor to work with virtually any chromatography system. Further, when the monitor is run with the TRILUTION LC software, the sample can be desalted automatically, which is especially important in manufacturing where efficiency is paramount.


Ease-of-use also extends to Gilson’s conductivity flow cells themselves. Gilson pre-calibrates each flow cell so they can be used out of the box at both room temperature (25ºC) and refrigerated conditions (4ºC). The flow cells can be exchanged between units without impacting data integrity, allowing users to focus on their science, rather than instrument calibration. An optional pH flow cell is available for real-time pH monitoring, which when combined with conductivity monitoring, can save time and provide users with more information to aid their separations.


The microplate-sized footprint of the VERITY 1810 Conductivity and pH Monitor takes up minimal bench space. A front panel display provides a readout of conductivity, pH, and temperature readings in real-time. No special software is required for instrument control.


Visit the website for further information: www.gilson.com/asia or email: asia-mea@gilson.com.


Fast Lyophilisation of HPLC Fractions


Fast Lyophilisation on the Genevac Series 3 HT Evaporator was developed to provide a rapid, high- throughput alternative to freeze drying HPLC purification fractions.


Traditional evaporation methods of removing solvents, such as water and acetonitrile, often results in formation of a gum or oil due to solvent interactions with the dissolved sample. Employing a Series 3 HT Evaporator with LyoSpeed™ Fast Lyophilisation technology is enabling pharma labs to now routinely dry HPLC fraction samples to a powder form, such that the samples can then be accurately weighed, easily sub-sampled and redissolved.


While standard evaporation works well for most hydrophilic samples, difficulties may arise where the sample cannot dissolve in only water. In such situations, when the organic solvent is removed, the sample sometimes crashes out forming an oil which until now required further processing to achieve the desired dry powder form. For such samples using a Series 3 HT Evaporator, with -75°C condenser and Fast Lyophilisation method, produces powdered samples from even the most difficult to handle compounds with a success rate as high as 95%.


For further information please visit: www.evaporatorinfo.com/info5.html, Tel: +44 (0)1473 240000 or Email: salesinfo@genevac.co.uk.


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