favor amyloid beta breakdown. Magnesium levels are markedly lower in AD patients, and the degree of deficiency of this critical mineral correlates with the severity of the disease.


Phosphatidyl Choline (PC) The body uses phosphatidylcholine to make the neurotransmit-


ter acetylcholine, critical for memory. Since PC increases acetyl- choline, there is keen interest in using it for improving memory and AD.


Pregnenolone Derived from cholesterol, pregnenolone is the parent hormone


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from which all other vital steroid hormones are made, including DHEA, estrogen, progesterone, and testosterone. Aging results in a dramatic decline in production of both pregnenolone and the hormones for which pregnenolone is a precursor. Science has linked decreasing levels of these essential hormones with many disorders that commonly accompany aging, including cognitive decline. Supplemental pregnenolone thus supports youthful cognition


by contributing to optimal hormone levels, supporting activity of acetylcholine (damage to the acetylcholine-producing system in the brain has been shown to be associated with AD memory deficits), and promoting nerve cell growth in the brain’s hippocampus. However, because pregnenolone can affect hormone levels, those with hormonally related cancers (e.g., prostate and breast cancers) should avoid it.


Lifestyle Choices To lower your dementia risk right now, try: (1) eating healthier;


(2) avoiding being overweight/obese; (3) staying physically active; (4) breaking addictions to sugar, smoking and prescription/illicit drugs; (5) managing your prescription side effects and drug-drug interactions; (6) sleeping 6-9 hours/night; (7) challenging your mind (see www.lumosity.com, WordsWithFriends); (8) managing your stress with cortisol-lowering nutritional supplements (e.g., Relora®), yoga, and deep breathing/meditation; (9) maintaining healthy cho- lesterol and blood pressure levels; and (10) taking anti-inflammatory and antioxidant supplements.


Conclusion While conventional medications cannot prevent progressive


brain deterioration, numerous nutritional supplements have been shown to bolster brain function and slow or prevent dementia. Regardless of which nutrients you choose, ideally in combinations, they will more likely be effective if you start using them early, long before memory loss symptoms appear.


Submitted by Michael Dworkin, PD, MS, CCN, a Registered Phar- macist and Connecticut Certified Clinical Nutritionist (CT Cert. No. 232), with J. Erika Dworkin, Nutrition Consultant, Certified Lifestyle Educator, Board Cert. Holistic Nutrition (pending). Owner of the Manchester Parkade Health Shoppe (860.646.8178, 378 West Middle Turnpike, Manchester), Pharmacist Dworkin has been guid- ing patients since 1956 and is available for consultation by appoint- ment. Erika is available to speak to groups and for weight loss con- sultations. References are available upon request. See ad on page 5.


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