CHROMATOGRAPHY 43
Fig. 1. The new AZURA Analytical HPLC systems bring high performance to routine analyses.
pharmacokinetic studies. Te new 15,000 psi-capable ACQUITY UPLC M-Class columns tap the potential of sub- two-micron particle technology, yielding faster separations, greater peak capacities and increased levels of sensitivity. .
Sensitivity improves chromatography studies
The greater sensitivity and faster separations offered by the latest chromatography technology open up new possibilities for lab scientists. Eugene McCarthy reports.
La sensibilité accrue et les séparations plus rapides offertes par la technologie chromatographique de pointe ouvrent de nouvelles possibilités aux scientifiques de laboratoire. Un article d’Eugene McCarthy.
Die größere Sensitivität und schnellere Trennungen, die die neueste Chromatographie-Technologie bietet, eröffnet im Labor tätigen Wissenschaftlern neue Möglichkeiten. Eugene McCarthy berichtet.
W
aters says its new ACQUITY UPLC M-Class System
is the industry’s first nano- to micro-scale ultra performance LC (UPLC) system rated for 15,000 psi operation. Coupled to the company’s mass spectrometers, the system delivers the sensitivity to quantify and to identify vanishingly small concentrations of key molecules.
Proteomics
Te system is ideally suited for a broad range of applications including proteomics, metabolic profiling,
metabolite identification and
Protein coverage “When scientists doing proteomics or investigating new biopharmaceuticals talk to us about the work they do, they often speak of protein coverage or being able to quantify and identify incredibly small amounts of key molecules usually in the presence of much higher amounts of other molecules. Tis is difficult work without the appropriate tools. With the ACQUITY UPLC M-Class System, they will have the capability to peer into the unseen and achieve their research goals,” said Art Caputo, president of the Waters Division. “As an LC inlet to mass spectrometers, the ACQUITY UPLC M-Class System empowers more scientists to reliably employ micro-scale chromatography in order to solve their most complex analytical challenges.”
Nano- to micro-scale LC is defined by flow rates of 200 nl/min to 100 µl/min. with columns having an internal diameter of up to 1.0 mm.
Te advantages include the conservation of sample and solvent, increased sensitivity and a flow rate compatible with high sensitivity electrospray ionisation mass spectrometry.
Te latest innovation from Shimadzu Scientific Instruments is the Nexera Method Scouting System. Capable of automatically investigating up to 96 combinations of mobile phases, gradients and columns, it significantly improves HPLC method development productivity in both R&D and QA/QC environments.
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