DRUG DISCOVERY AND DEVELOPMENT 39
of the top of the tablet.
n Consumer acceptance as the FFRE tablet has a softer look and is more appealing to the consumer and generally has a better mouth feel.
Tere are enough advantages of the FFRE tablet design over the FFBE design that it should be considered for all new tablet designs for coated and non- coated tablets, hence someday making the FFBE design obsolete.
Te same holds true with Concave Bevel edge tablets (CCBE) – Fig. 3 – commonly used on both round and shaped tablets to assist in reducing edge attrition during the coating process. Again, the radius edge would make a better and more robust design, generally allowing an increase in maximum compression force over the CCBE.
Designing tablets can be gratifying and provides a
Fig. 3. The concave bevel edge typically is a weaker tool design than the compound cup.
sense of ownership when all goes well. But when things go astray, it becomes anything but gratifying. A final tablet design should consider comments from all departments responsible. Considering comments from all departments will empower all involved and ensure a successful
and timely launch – and the enjoyment of an efficient, trouble-free tableting operation.
For more information ✔ at
www.scientistlive.com/eurolab Dale Natoli is president of Natoli
Engineering Company Inc, St Charles, MO, USA.
www.natoli.com
Eurolab-Micro-horz
advert.indd 1
For more information ✔ at
www.scientistlive.com/eurolab
02/05/2014 11:38:13
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