ISSUES AND POLICY
®
150 mg/mL ANTIMICROBIAL NADA 141-328, Approved by FDA For subcutaneous injection in beef and non-lactating dairy cattle only. Not for use in female dairy cattle 20 months of age or older or in calves to be processed for veal.
(gamithromycin)
Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. READ ENTIRE BROCHURE CAREFULLY BEFORE USING THIS PRODUCT.
INDICATIONS ZACTRAN is indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis in beef and non-lactating dairy cattle. ZACTRAN is also indicated for the control of respiratory disease in beef and non-lactating dairy cattle at high risk of developing BRD associated with Mannheimia haemolytica and Pasteurella multocida.
CONTRAINDICATIONS As with all drugs, the use of ZACTRAN is contraindicated in animals previously found to be hypersensitive to this drug.
WARNING: FOR USE IN CATTLE ONLY. NOT FOR USE IN HUMANS. KEEP THIS AND ALL DRUGS OUT OF REACH OF CHILDREN. NOT FOR USE IN CHICKENS OR TURKEYS. The material safety data sheet (MSDS) contains more detailed occupational safety information. To report adverse effects, obtain an MSDS or for assistance, contact Merial at 1-888-637-4251.
RESIDUE WARNINGS: Do not treat cattle within 35 days of slaughter. Because a discard time in milk has not been established, do not use in female dairy cattle 20 months of age or older. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.
PRECAUTIONS The effects of ZACTRAN on bovine reproductive performance, pregnancy, and lactation have not been determined. Subcutaneous injection of ZACTRAN may cause a transient local tissue reaction in some cattle that may result in trim loss of edible tissues at slaughter.
ADVERSE REACTIONS Transient animal discomfort and mild to moderate injection site swelling may be seen in cattle treated with ZACTRAN.
EFFECTIVENESS The effectiveness of ZACTRAN for the treatment of BRD associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni was demonstrated in a field study conducted at four geographic locations in the United States. A total of 497 cattle exhibiting clinical signs of BRD were enrolled in the study. Cattle were administered ZACTRAN (6 mg/kg BW) or an equivalent volume of sterile saline as a subcutaneous injection once on Day 0. Cattle were observed daily for clinical signs of BRD and were evaluated for clinical success on Day 10. The percentage of successes in cattle treated with ZACTRAN (58%) was statistically significantly higher (p<0.05) than the percentage of successes in the cattle treated with saline (19%). The effectiveness of ZACTRAN for the treatment of BRD associated with M. bovis was demonstrated independently at two U.S. study sites. A total of 502 cattle exhibiting clinical signs of BRD were enrolled in the studies. Cattle were administered ZACTRAN (6 mg/ kg BW) or an equivalent volume of sterile saline as a subcutaneous injection once on Day 0. At each site, the percentage of successes in cattle treated with ZACTRAN on Day 10 was statistically significantly higher than the percentage of successes in the cattle treated with saline (74.4% vs. 24% [p <0.001], and 67.4% vs. 46.2% [p = 0.002]). In addition, in the group of calves treated with gamithromycin that were confirmed positive for M. bovis (pre-treatment nasopharyngeal swabs), there were more calves at each site (45 of 57 calves, and 5 of 6 calves) classified as successes than as failures. The effectiveness of ZACTRAN for the control of respiratory disease in cattle at high risk of developing BRD associated with Mannheimia haemolytica and Pasteurella multocida was demonstrated in two independent studies conducted in the United States. A total of 467 crossbred beef cattle at high risk of developing BRD were enrolled in the study. ZACTRAN (6 mg/kg BW) or an equivalent volume of sterile saline was administered as a single subcutaneous injection within one day after arrival. Cattle were observed daily for clinical signs of BRD and were evaluated for clinical success on Day 10 post-treatment. In each of the two studies, the percentage of successes in the cattle treated with ZACTRAN (86% and 78%) was statistically significantly higher (p = 0.0019 and p = 0.0016) than the percentage of successes in the cattle treated with saline (36% and 58%).
Marketed by Merial Limited 3239 Satellite Blvd., Duluth, GA 30096-4640 U.S.A. Made in Austria
®ZACTRAN is a registered trademark of Merial Limited. ©2012 Merial Limited. All rights reserved. Rev. 03/2012
The Year Ahead Farm bill, beef checkoff top issues for National Cattlemen’s Beef Association leader
By Scott George, NCBA president O
VER THE PAST SEVERAL WEEKS I’VE BEEN ASKED ABOUT MY PRIORITIES FOR MY term as NCBA president. As an NCBA offi cer, my response has al- ways been to look toward the membership for direction. However,
I do think there are a couple of important items that will surface over the year ahead. Those issues are the farm bill debate, which Congress has delayed, and the discussion about beef checkoff resources and the future of our industry as cattle herd numbers continue to decline. As you might know, I have a slightly different perspective on this in-
dustry. I started my role in cattle industry leadership serving as the dairy representative on the Wyoming Beef Council in 1991. My family owns a dairy and beef cow farm in Cody, Wyo., where the third generation is working its way into the operation. Five cousins are joining the operation, and each of them brings a dif-
ferent skill set to the farm. It has been interesting and rewarding to be a part of that succession process but, as many of you know fi rsthand, it also presents challenges in the current operating environment. The drought, tight credit markets and rising costs have taken a toll
on our industry, but perhaps none are as diffi cult to cope with as the legislative and regulatory burdens placed on our shoulders by state and federal offi cials. As an offi cer I have seen how hard our NCBA team in Washington,
D.C. works on behalf of our members and this industry. During the recent fi scal cliff calamity, our staff worked through the holidays to keep the death tax and other agriculture issues front and center on Capitol Hill. A base membership in NCBA is $100, and I strongly believe that’s in-
expensive insurance in today’s operating environment. Many of us would spend that on a gate and never blink, so an investment of that amount to have someone represent you and your interests in our nation’s capitol makes sense. But it isn’t just NCBA where your support is needed. We’re dealing with
a public that no longer understands agriculture. I encourage each of you to belong to your state cattlemen’s organizations. You need representation at the local level, and your organizations have that united voice that can protect your interests. State legislators too often have good intentions, but they don’t always
understand how their actions can impact agriculture. Your state associa- tion has the ability to visit with legislators, educate them and stop many problems before they get started. It’s important that we speak with a single, united voice going forward.
ZACTRAN-PI-thirdpage-MBovis_THE
CATTLEMAN_FA.indd 11/3/13 11:38 AM 104 The Cattleman March 2013
thecattlemanmagazine.com
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