| FUTURISTIC APPROACHES TO SKIN CARE | arTicle References
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placebo both significantly improved dermal texture and hypodermal echogenicity and texture. Day 84 measurements were not reported due to technical difficulties with the ultrasound apparatus. Regarding mechanical characteristics of the skin, both product and placebo firmed the skin and no significant differences in effect were observed. Mean blood flow increased with both active product and placebo, but was greater and more persistent with active product, probably due to the presence of ruscogenine extract (51,54). Differences did not achieve statistical significance. The placebo effect in skin firmness and mean blood flow
may be attributed to massage alone as active product and placebo were applied (57). Another factor was the presence of ethyl alcohol in both active product and placebo; ethyl alcohol may qualitatively alter free fatty acids in plasma (58,59). The authors concluded that active product was more
effective than placebo in decreasing skin macrorelief, which is responsible for the “orange peel” appearance of the skin, and that the skin microcirculation was more
prime-journal.com | March 2011
improved by active product than by placebo. The combination of different methods of evaluation showed that the active product was generally superior to placebo in improving the appearance of cellulite. On the basis of the results of this study, a topical
formulation (ROC®, Johnson & Johnson) containing retinol, caffeine, and ruscogenine in an oil–water emulsion has been developed and released as a non-prescription therapy for the treatment of cellulite. It can be used in all skin types and is the first anti-cellulite treatment containing retinol.
Declaration of interest Neil Sadick is an Advisor for Christian Dior, LVMH Inc.
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