Sequencing
define a single research object that combines all of the computational steps and their parameters (using the CWL), as well as all of the input, inter- mediate and output data, into a single object that can be referenced by a unique accession identifier. Reproducible analysis frameworks could create these BCOs for submission to regulatory agen- cies, and they could be re-executed in a different environment to reproduce the analysis from start to finish.
Technology service providers There is now a thriving market for solutions to the technical infrastructure needs of NGS practition- ers, specifically including those working in regulat- ed environments. The volumes of data generated are huge and the computational burdens are simi- larly large, and often transient. NGS analysis envi- ronments must accommodate large-scale data transfer and storage, metadata management, workflow management, data provenance, data
archiving and access to public databases. This must all be provided in an environment that supports data encryption and security, access control and auditing and data centre management according to standards such as ISO27001/27002. Furthermore, it must be easily scalable in order to handle the next project or batch of samples, but without the high overhead of a fixed infrastructure that sits idle between projects.
All of these characteristics point naturally to host- ed Platform-as-a-Service (PaaS) or Software-as-a- Service (SaaS) solutions. Companies such as DNAnexus, Bluebee and Seven Bridges Genomics provide NGS-tailored PaaS/SaaS environments built on existing infrastructure providers such as Amazon Web Services, Microsoft Azure or Google Cloud. They provide ready access to the tools and databases typically used for NGS analyses and allow customi- sation, sharing and reuse of genomic analysis pipelines. These providers can also help manage data localisation, where particular countries or
33rd
International Exhibition for Fine and Speciality Chemicals
The industry’s premier sourcing and networking event
Some 400 international exhibitors off er bespoke solutions and specifi c substances to enhance
products or develop new chemical solutions.
Fine and speciality chemicals for various industries:
pharmaceuticals • agrochemicals • petrochemicals • cosmetics • adhesives & sealants • paints & coatings • polymers • biotechnology • colourants & dyestuff s • food & drink • industrial cleaning • reprography & printing • water treatment and much more.
Organisers:
20 – 21 JUNE 2018 Koelnmesse
Cologne, Germany
www.chemspeceurope.com
Drug Discovery World Winter 2017/18
67
Top conferences and workshops off er
valuable insights into ongoing R&D projects!
Agrochemical Lecture Theatre Chemspec Careers Clinic Pharma Lecture Theatre
Regulatory Services Lecture Theatre RSC Lecture Theatre Innovative Start-ups
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