Contents
DDW the quarterly business review of drug discovery & development
Publisher and Editor-in-Chief Robert Jordan
Robert@rjcoms.com
Digital & Circulation Manager Giles Jordan
Consultant Editor Dr Roger Brimblecombe
Contributing Author Dr John Comley
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Dr Rathnam Chagaturu Dr David Clough Dr Richard Eglen Dr Gregory Lennon Dr Keith Mansford Dr Stephen Naylor Dr George Poste Dr Amber Salzman Dr David U’Prichard Dr Timothy Wells Dr Rene Ziegler
Drug Discovery World (ISSN 14694344) is published quarterly by RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8ET, United Kingdom. Tel: +44 (0)20 8487 5656 Fax: +44 (0)20 8487 5666 E-mail:
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dr ug discov e r y wo r l d contents
VOLUME 19 ISSUE 1 ●WINTER 2017/18 Introduction
Dr Roger Brimblecombe Consultant Editor
Therapeutics New Tools to Enhance the Antibody Drug Pipeline Dr Robert Ford and Dr Toni Hoffman
Compound Management Technology Innovation Will Help Prepare Drug Discovery For Smart Screening Era
Dr Clive Green and Dr Philip Spencer Business
Emerging Drug Discovery Alliance Models
Dr Swati Prasad, Mary Louise Bell and Dr Charles McOsker Screening
Automating Flow Cytometry for Cell-Based Screening in Drug Discovery Paul Avery and Richard Massey
Cell Culture High-Throughput Spheroid Culture
Hilary Sherman, Dr Richard Eglen and Audrey Bergeron Drug Development
Breaking Down Silos in Drug Development – Why Interdisciplinary Integration is Fundamental for Pharma’s Future Dr Paul Overton
Drug Delivery
Discovery and Development of Inhaled Pharmaceuticals – The Impact and Effective Routes of Non-Clinical Safety Assessment of Inhaled Biopharmaceuticals
Dr Simon Moore, Dr Kirsty Harper and Dr Sylwia Marshall Drug Discovery
Practicalities of Conducting Replication Studies Dr Nicole Perfito, Dr Rachel Tsui and Dr Elizabeth Iorns
Next-Generation Sequencing
Use of Next-Generation Sequencing in the Regulated Domain of Drug Development
Keith Nangle and Mike Furness
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Front cover illustration courtesy of Alfred Pasieka/Science Photo Library Drug Discovery World Winter 2017/18 5
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