Contents


DDW the quarterly business review of drug discovery & development


Publisher and Editor-in-Chief Robert Jordan Robert@rjcoms.com


Digital & Circulation Manager Giles Jordan


Consultant Editor Dr Roger Brimblecombe


Design & Production Melissa Chadderton rhubarbcreative@sky.com


Editorial Advisors Dr Steve Arlington Dr Nigel Brown Dr Rathnam Chagaturu Dr David Clough Dr Richard Eglen Dr Gregory Lennon Dr Keith Mansford Dr Stephen Naylor Dr George Poste Dr Amber Salzman Dr David U’Prichard Dr Timothy Wells Dr Rene Ziegler


Drug Discovery World (ISSN 14694344) is published quarterly by RJ Communications & Media Ltd, 39 Vineyard Path, London SW14 8EL, United Kingdom. Tel: +44 (0)20 8487 5656 Fax: +44 (0)20 8487 5666 E-mail: Robert@rjcoms.com


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© 2018 RJ Communications & Media Ltd All rights reserved.


No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the copyright holder. While the publishers believe that all information contained in this publication was correct at the time of going to press, they can accept no liability for any inaccuracies that may appear or loss suffered directly or indirectly by any reader as a result of any advertisement, editorial, photographs or other material published in Drug Discovery World.


Front cover illustration courtesy of Alfred Pasieka/Science Photo Library Drug Discovery World Fall 2018 5


d r u g d i s c o v e r y wo r l d contents VOLUME 19 ISSUE 4 ● FALL 2018


Introduction Dr Roger Brimblecombe Consultant Editor


Drug Discovery The Future of Drug Discovery – Cutting Edge Technologies Meet Traditional Paradigms in Assay Development Dr Roger Bossé


Therapeutics Current Trends in RNA-Based Therapeutic Development Dr Xiaoqiu Wu and Dr Andrew P. Turnbull


Genomics Genetically-Engineered Models: The Value of Precious Gems Dr Megan M. MacBride


Business Emerging Paradigm of Integrated Platform-Drug Discovery and Development Companies Dr Urban A. Kiernan and Dr Stephen Naylor


Stem Cells Unlocking the Full Potential of Induced Pluripotent Stem Cells for Drug Discovery Abbey Edwards and Dr Richard Massey


Drug Discovery How Phenotypic Screening is Revolutionising Drug Discovery Dr Steffen Lawo and Dr Carlos le Sage


Therapeutics Therapeutics Discovery at MD Anderson – Making Patients a Priority During the Drug Development Process Dr Phil Jones


Pharmacokinetics Hepatic Model Helps to Predict Clinically-Relevant Botanical-Drug Interactions Dr Amy L. Roe and Dr Jonathan P. Jackson


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