Stem Cells


Corning Life Sciences provides advanced cell cul- ture technology to ensure stem cell viability, repro- ducibility and regulatory compliance. The compa- ny specialises in innovative solutions for the gener- ation of in vivo-like 3D models, such as Ultra-Low Attachment vessels, Corning Matrigel® matrix and Transwell® permeable supports. Corning recently added a 1536-well Spheroid Microplate to its line of Spheroid plates. To help streamline work with 3D cell cultures in an automated environment, the 1536-well spheroid microplate features a novel and proprietary design that allows scientists to generate, culture, assay and analyse 3D multicellu- lar spheroids in one microplate. The spheroid microplate eliminates the need for a transfer step in visualisation or biochemical assays, reducing the risk of cell damage or loss. The 1536-well format takes spheroid plates out of the research lab and into high-throughput


screening, enabling


researchers to drive a larger volume of compounds through drug screening in less time, using a more physiologically relevant 3D cell culture (Figure 2).


Miltenyi Biotec offers a range of instruments and reagents to drive a standardised approach to gen- erating iPSCs. The company’s CliniMACS Prodigy Platform provides a fully-automated, closed-sys-


tem approach to generating differentiated cells. All protocol steps during cell culture and differentia- tion, including passaging, timed cytokine exposure


Figure 2 Advances in 3D stem cell models are helping to break barriers in drug discovery. The 1536-well spheroid microplate from Corning allows scientists to generate, culture, assay and analyse 3D multicellular spheroids in one microplate


Figure 3 Advances in automated devices for stem cell differentiation improve standardisation, cost reduction and high-throughput capabilities. The CliniMACS Prodigy Platform from Miltenyi Biotec is a fully-automated, closed-system approach to generating differentiated cells


Drug Discovery World Fall 2018 49


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