CHEM


nual testing of individuals’ genomes. Today’s automated, high-throughput screening is allowing scientists to access a huge amount of data with little manual iinteraction. This keeps costs low and creases the speed at w ich the system can analyse gene sequences.


nteraction. This keeps costs low and increases the speed at which the system can analyse gene sequences.


Automated systems also have the capabiility to analyse information including patient medical histories, genotype data, familial inheritance and biomedical research. With this in-depth automated data analysis and intelligent iinterpretation, it is possible to buiildld individual clinical and molecular profiles of each patient and use this to personal e m dicine and care.


ca


Automated systems also have the lity to


yse informatio


cluding patient medical histories, genotype data, fam al biomedi al research. to


th thi ted


nterpretatio ndividual


ta a ysis a it is p al and m sible to ar prof es


of each patient and use this to personalise medicine and care.


ROBO ICS IN HE LABORAT The pharmaceutical industry iis


ROBOTICS IN THE LABORA OR The pharmaceutical ndustry


ATORY


creasingly making use of robotics to automate specific processes in drug development, including drug screening, anti-counterfeiting and manufacturing tasks. Today, processes such as nuclear agnetic resonance (NMR) and high performance liquid chromatography (HPLC) can have sam e preparati carried out by robotic arms.


increasingly making use of robotics to automate specific processes i development, anti-counterfei


drug


cluding drug screening, g and m nufacturing


tasks. Today, processes such as nuclear magnetic resonance (NMR) and high performance liquid chromatography (HPLC) can have sample preparation carried out by robotic arms.


Additionally, structural protein analysis can be done by automati al y using a combination of NMR and X-ray


Additional y, structural protein analysi can be done by automatically using a combination of NMR and X-ray


crystal graphy. X-ray crystal graphy i an ian important technique used in drug discovery and involves the detailed analysis of crystal structures of protein- ig


drug co lexes. T is allo for th


study of specific i teractions between a particular drug and its protein target at the atomic level. This process often takes hundreds to thousands of


crystallography. X-ray crystallography is portant technique used i


discovery and i volves the detai ed analysis of crystal structures of protein- lligand complexes. This allows for the study of specific interactions between a particular drug and its protein target at the atomc level. This process often takes hundreds to thousands of


PLUG AND PRODUCE SOFTWARE SOLUTION FOR PHARMA nd Werum IT Solutions have collaborated


WA A


The new on a BB a


and si Solutions have collaborated


on a plug and produce solution for Pharma 4.0. The new software connects systems and equipment in biotech production to reduce engineering efforts and simplify qualification to satisfy compliance. Today,many solutions for the pharmaceutical and biotech industry are still not or integrated, requiring more effort to engineer and synchronise data betweenMES (Manufacturing Execution Systems) and DCS (Di tributed Control Systems). Especial y i GMP plants (GMP = Good Manufacturing Practices) thi additional work has a crucial o m ket qual y and prof abi software m dule from


Today, biotech industry are sti


plug and produce solution for Pharma 4.0. software connects systems and equipment biotech production to reduce engineeri g efforts lify qualificati n to satisfy compliance. ny solutions for the pharmaceuti al and not or i tegrated, requiring


re effort to engineer and synchronise data


between M S (Manufacturing Executi n Systems) and DCS (Distributed Control Systems). Especially in GMP plants (GMP = GoodManufacturing Practices) this additional work has a crucial influence on time tomarket, quality and profitability. ABB had added a softwaremodule fromWerumIT Solutions to its Manufacturing OperationsManagement solution to address this challenge.


fluence on ti y. ABB had added a rum IT Solutions to i


nufacturing Operations M nagement solution to address this challenge.


that wi


GE Healthcare i among one of the first customers that will implement this Plug & Produce solution.


GE Healthcare is among one of the first customers plement this Plug & Produce sol tion.


Uppsala, Sweden,


PLUG AND PRODUCE SOFTWARE SOLUTION FOR PHARMA 4. BB and W rum


The ‘Shop Floor Integration for Life Sciences’module is a new addition to the ABB Ability M nufacturing Operations M nagement (MOM) offering. At i anufacturing site i


The ‘ hop Floor I tegration for Life Sciences’ is a new addition to the ABB AbilityManufacturing OperationsManagement (MOM) offering. At it manufacturing site in Uppsala, Sweden, which has one of the world’s largest installed capacities for production of chromatographic resins, GE Healthcare wi use the new approach to i tegrate the


MA 4.0 odul


h has


one of the world’s largest i stalled capacities for production of chromatographic resins, GE Healthcare will use the new approach to integrate the


automation and equipment level for the production of a chrom tography m dium erum


automation and equipment level for the production of a chromatographymedium. S PAS-X from


MES PAS-X from Werum will be integrated with ABB’s Process Control System 800xA: ABB and erum have agreed on a l ng-term roadmap for an aligned offerin. Customers wi


be i tegrated with


ABB’s Process Control System 800xA: ABB and Werum have agreed on a long-term roadmap for an al gned offerin. Customers will benefit from si


benefit from


simplified operation, faster m ster batch record (MBR) creation and a joint deployment and val dation approach.


(MBR) creation and a j validation approach.


ABB ABB


ied operation, faster master batch record t deployment and


abb.co .com/lifescie ce /lifesciences


heritance and -depth


intelligen


scientists often become hampered by the manual testing of individuals’ genomes. Today’s automated, high-throughput screening is allowing scientists to access a huge amount of data with l


Without automati scientists often bec


thout automation and robotics,


ome hampered by the on and robotics,


tle manual


HEMIICALS & PHARMACEU


suitable for X-ray crystal graphy. An automated micropipette machine can alllow nearly a million different crystals to be created at once and analysed using X-ray crystallography.


experiexperiments to create a protein crystal suitable for X-ray crystallography. An automated mcropipette machine can lo


nts to create a protein crystal rly illio fferent crystals


to be created at once and analysed using X-ray crystallography. Despite these benefits,


Despite these benefits, many pharmaceutical


ny


pharmaceutical manufacturers are still wary of robotics. Worries relating to cost, ease of use and acceptance by staff often discourage companies fromadopting the technology.


nufacturers are sti


ry of robotics. W rries relating to cost, ease of use and acceptance by staff often discourage companies from adopting the technology.


In reality, robotic technology can be a great i vestment. Return on i vestment often comes in the formof energy savin s, flexibility, h


ed


production and increased quality. More recentlrecently, robotic technology is also becoming more accessible for smaller businesses as the cost is decreasing and they are becomng easier to use.


re


The pharm ceutical ndustry has com a long way since the manual processes


becomng m re accessible for smaller businesses as the cost is decreasing and they are becoming easier to use.


The pharmaceutical industry has come a long way since the m nual processes


real y, robotic technology can be a great investment. Return on investment often comes in the form of energy savings, flexibility, high-speed production and i creased qual y. robotic technology i also


The pharmaceutical industry produces


he pharmaceutical industry produces


millions of tablets each week, all of which must


millions of tablets eac week, all of which must be carefully scrutbe carefully scrutinisedinised before being packed and


before being packed and shipped to distshipped to distributorsributors


EUTICALS


INDUSTRY F


STRY FOCUS


used in the 1800s. Companies rely on automated processes and m chinery running precisely, around the clock i order to meet distributors' deadl produce medicine on ti


es breaks.


used in the 1800s. Com anies rely on automated processes and machinery running precisely, around the clock in order to meet distributors' deadlines and produce medicine on time. However, the pharmaceutical industry is no different to the sense that m chinery


es and e. However, the


pharmaceutical ndustry i no different to any others iany others in the sense that machinery sometisometimes breaks. som


contacting the ori


In some industries, it’s as easy as contacting the original equipment


dustries, al equi


as easy as nt


manufacturer and ordering a replacement part. H


nufacturer and ordering a replacement part. However, more commonly in the pharmaceutical industry, companies have egacy systems due to the need to compl th strict m chinery regulations. W en these parts break, pharmaceutical


ver, m re com only in the


pharm ceuti al ndustry, com anies have llegacy systems due to the need to comply with strict machinery regulations. When these parts break, pharmaceutical


EU Automation T: 0845 521 3088 euautomation.com


EU Automation T: 0845 521 3088


euautomation.com are already on your approved suppl er l st.


nufacturers often find that they have in fact become obsolete since their last purchase and are much more difficult to get hold of.. This is where working with a specialised obsolete parts suppllier comes iin particularly handy, especially if they are already on your approved supplier list.


manufacturers often find that they have fact become obsolete since their l st purchase and arem chm re difficult to t h ld


T is is w ere


specialised n


rticu solete p rts su ly h rkin th ier co , esp cia ly if they


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