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Drug delivery
The viscosity Y 8
ou don’t need to be a formulation scientist to know it’s harder to push honey through a syringe than it is water. It’s because honey is much more viscous, so it takes more force to drive it through and out of a needle. Liquid drugs that
problem
It’s no surprise that the physical characteristics of an injectable substance will have a bearing on how it functions inside the body. But exactly what those effects are may not be so intuitive. Viscosity is a good example here, as it has an impact on the pressure required to push the drug through the needle and into the injection site, but can also affect the level of pain experienced by patients. This latter effect can be detrimental for self-administered injectables, where the experience of pain and discomfort may lead to non-adherence. And yet, reducing viscosity while maintaining the stability of a drug is no easy feat. Monica Karpinski speaks to experts in formulation science and injectable devices to discuss this viscosity problem, and what can be done to tackle it.
contain high concentrations of large and complex molecules, such as biologics, or that have molecules that can form bonds with each other, pose a similar problem: they’re often too thick and don’t flow easily enough to be delivered through standard
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