Company insight
Simplifying small molecule synthesis
Keeping up with the modern-day demands of pharmaceutical research has necessitated advancements in rapid production of small molecules and peptides. Mimotopes leads the pack with the invention of solid substrates to speed up reaction times.
O
ptimised for the synthesis of small organic molecules or peptides, SynPhase Lanterns are modular solid substrates that hold discrete quantities of single compounds. These are also applied in extracting contaminants or final products from solution-phase reactions.
The rapidly changing landscape of pharmaceutical and medical research demands new innovative products to adapt quickly or be left behind. Mimotopes has introduced tagging and compound-identification systems to SynPhase lanterns to expand applications into the realms of combinatorial and large-scale synthesis. The broad variety of tag types including colour coded, radio frequency and multiple array tagging, ensures there’s always a suitable option for quick identification – designed in a way that will never interfere with experimental procedures.
Faster preparation and better yields
Once considered crucial, many stages of conventional resin preparation and procedures are completely bypassed by SynPhase lanterns. There’s no need for
weighing, filtering, column preparation or recrystallisation, saving the user valuable time with each synthesis. Like resins, lanterns are small enough to remain compatible with the same tried-and-true reaction vessels and synthesisers, including the modern microwave synthesiser. Unlike resins, lanterns have the additional advantage of being large enough to handle easily. It’s much simpler to transfer lanterns between flasks; they don’t leave behind particles, clog filters or disappear down drains like conventional resins. The unique shape and compact design of these lanterns allows unimpeded free-flow of the reactants, which gives superior performance over resin, as well as better yields. In use, SynPhase lanterns allow for smaller working volumes and higher reagent concentrations, quickly driving reactions to completion.
A series of examples describing the applications of different lanterns. Functionalisation
Chemistry application Sulphonic Acid Aminomethyl TMI Isocyanate N-Methyl Morpholine o-Nitrophenol Benzaldehyde
Scavenges primary, secondary and tertiary amines by quarternary salt formation.
Scavenges acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles.
Scavenges primary and secondary amines but does not scavenge anilinic type aromatic amines.
Supported tertiary amine for acylations and sulfonylations.
Solid supported active-ester used for synthesis of amides and sulfonamides.
Scavenges various nucleophiles including amines, hydrazines and carbon-based nucleophiles such as phenylmagnesium halides.
World Pharmaceutical Frontiers /
www.worldpharmaceuticals.net
A detailed breakdown of the SynPhase lantern’s main components, and an example of its scavenging process.
Modular and adaptable system This is the only medium to combine the advantages of solid-phase and solution-phase chemistry into one system, overcoming the limitations of both, whilst remaining compatible with all the same equipment, reagents, and temperatures. Instead of weighing resin, select from a series of preset lantern sizes and loading levels. The already vast potential of lantern applications only further diversifies with the introduction of a variety of linkers, tags and surface functionalities now available to choose from. In the ever-shifting landscape of pharmaceutical research, modular SynPhase lanterns continue to be developed to suit new applications as they arise. ●
www.mimotopes.com 41
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