FOR ADULTS WHO HAVE TYPE 2 DIABETES AND HEART DISEASE


HOW DOES TYPE 2 DIABETES AFFECT YOUR HEART?


Type 2 diabetes and cardiovascular (CV) disease go hand in hand. That’s why JARDIANCE goes beyond lowering A1C to also reduce the risk of CV death for adults who have type 2 diabetes and heart disease. When it comes to type 2 diabetes treatments, Jardiance is the first diabetes pill to offer this lifesaving CV benefit.


JARDIANCE IS PROVEN TO: TO:


Reduce the risk of dying from a CV event


Lower A1C, along with diet and exercise


WHAT IS JARDIANCE? JARDIANCE is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes. JARDIANCE is also used to reduce the risk of cardiovascular death in adults with type 2 diabetes who have known cardiovascular disease. JARDIANCE is not for people with type 1 diabetes or for people with diabetic ketoacidosis (increased ketones in the blood or urine).


IMPORTANT SAFETY INFORMATION


Do not take JARDIANCE if you are allergic to empagliflozin or any of the ingredients in JARDIANCE.


Do not take JARDIANCE if you have severe kidney problems or are on dialysis. JARDIANCE can cause serious side effects, including:


• Dehydration. JARDIANCE can cause some people to have dehydration (the loss of body water and salt). Dehydration may cause you to feel dizzy, faint, light- headed, or weak, especially when you stand up. You may be at a higher risk of dehydration if you:


• have low blood pressure • take medicines to lower your blood pressure, including water pills (diuretics)


• are on a low salt diet • have kidney problems • are 65 years of age or older.


• Vaginal yeast infection. Women who take JARDIANCE may get vaginal yeast infections. Talk to your doctor if you experience vaginal odor, white or yellowish vaginal discharge (discharge may be lumpy or look like cottage cheese), and/or vaginal itching.


• Yeast infection of the penis. Men who take JARDIANCE may get a yeast infection of the skin around the penis, especially uncircumcised males and those with chronic infections. Talk to your doctor if you experience redness, itching or swelling of the penis, rash of the penis, foul smelling discharge from the penis, and/or pain in the skin around penis.


• Ketoacidosis (increased ketones in your blood or urine). Ketoacidosis is a serious condition and may need to be treated in the hospital. Ketoacidosis may lead to death. Ketoacidosis occurs in people with type 1 diabetes and can also occur in people with type 2 diabetes taking JARDIANCE, even if blood sugar is


less than 250 mg/dL. Stop taking JARDIANCE and call your doctor right away if you get any of the following symptoms, and if possible, check for ketones in your urine:


• nausea • vomiting


• stomach-area (abdominal) pain


• tiredness • trouble breathing


• Kidney problems. Sudden kidney injury has happened in people taking JARDIANCE. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or being in the sun too long.


• Serious urinary tract infections. Serious urinary tract infections can occur in people taking JARDIANCE and may lead to hospitalization. Tell your doctor if you have symptoms of a urinary tract infection, such as a burning feeling when passing urine, a need to urinate often or right away, pain in the lower part of your stomach or pelvis, or blood in the urine. Sometimes people also may have a fever, back pain, nausea or vomiting.


• Low blood sugar (hypoglycemia): If you take JARDIANCE with another medicine that can cause low blood sugar, such as sulfonylurea or insulin, your risk of low blood sugar is higher. The dose of your sulfonylurea or insulin may need to be lowered. Symptoms of low blood sugar may include:


• headache • drowsiness • weakness • dizziness


• confusion • irritability • hunger • fast heartbeat


• sweating • shaking or feeling jittery


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