of the modulation of inflammatory and anti-oxidant status, and of a lower fat mobilisation reserve, an improvement of milk production by +2.3 kg/cow/day was observed for the treated group during the first three months of lactation.

Synergistic effects of plants extracts Many types of stresses can trigger inflammatory, oxidative stress and immune system warning reactions, which are ma- jor challenges in farm animals’ life, causing a lack of perfor- mance and profitability. Combining plant extracts with differ- ent properties delivers greater benefits from synergies, enabling animals to better face inflammatory and oxidative processes around sensitive and stressful periods. The combi- nation of plant extracts dedicated to swine, poultry and rumi- nant acts on the preservation of gut health by preventing leaky gut. Thus, better nutrient absorption and better nutri- ent use by the animals occurred when they face a stress peri- od that causes inflammation. More energy is allocated to pro- duction instead of amplifying the inflammatory process, leading to an improvement in the animals’ performance.

Table 1 – Results of the in vitro research. No inflam-


challenge Negative Positive control

control Alkaloids TEER

(mOhm/cm²) Basal IL 8

of each group one week before calving and one week after calving in order to evaluate their inflammatory and oxidative status. Haptoglobin was selected as a positive inflammatory marker and Super Oxide Dismutase (SOD) as a marker of oxi- dative stress. The plant# extracts combination limited the in- crease of haptoglobin concentration, demonstrating that it helped to limit inflammation. A strong increase of SOD activi- ty was observed and this demonstrated that the plant ex- tracts combination reinforced the anti-oxidant capacity of the animals. the calving period is associated with an energetic (carbohydrates and amino-acids) deficit and consequently with fat reserve mobilisation. To evaluate this phenomenon, two blood markers were analysed: the level of NEFA (Non-Es- terified Fatty Acids) and of BHB (Betahydroxibutyrate) one week after calving. The group supplemented had lower NEFA and BHB concentrations compared to the control group. This suggests lower fat reserves mobilisation during the peri-par- tum period for the dairy cows supplemented with the plant extracts and consequently an energy deficit less severe dur- ing the beginning of the lactation period. As a consequence

secretion (pg/mL) a, b, c with P< 0.05

Table 2 – Fields trials results on dairy cows. Difference after/

Negative control before calving

Haptoglobin (mg/mL) SOD (U/g d’Hb) After calving

NEFA (mmol/L) BHB (mmol/L)

Milk production (kg)

1st three months of lactation

▶ ALL ABOUT FEED | Volume 28, No. 8, 2020 33

0.39 -231

Negative control

0.85 1.98 28.7


(Alkaloids + Neolignan) 0.17 241


(Alkaloids + Neolignan) 0.61 1.37 31.0

-56% 204%

Variation (%)

-26% -31%

+8.0% 343.7a 13.73a 241.1b 609.8b 262.1b 613.0b Neo lignans 265.7b 520.9b

(Alkaloids + Neolignan) 304.4c

429.7c Extract 1

WITH inflammatory challenge (cytokines cocktail)

Extracts 2 + 3 POWERJET

Variation (%)


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