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PLANT EXTRACTS ▶▶▶


Calving is a stressful period which is charac- terised by a sud- den increase in energy require- ments, what can lead to an in- crease in intesti- nal inflamma- tion and oxidative stress.


neo-lignans alone did not lead to any intestinal integrity im- provement. With the inflammatory challenge, basal IL-8 se- cretion is significantly increased meaning that the challenge is working. The combination of plants extracts decreased the secretion of basal IL-8 proving is ability to limit the over acti- vation of the immune system after an inflammatory chal- lenge where alkaloids or neo-lignans alone were not able to reduce the secretion of basal IL 8. These results assess the in- terest of such a patented combination and prove its synergis- tic effect on two important criteria. First on the preservation of intestinal integrity, avoiding leaky gut syndrome. Second on the modulation of the immune response to an inflamma- tory challenge, dedicating more nutrients for production needs instead of repairing damaged cells or supporting the immune response when animals are facing a stress period that generates inflammation.


In vivo benefits The benefits of a combination of plant extracts on animal performances has been demonstrated in several R&D and


32 ▶ ALL ABOUT FEED | Volume 28, No. 8, 2020


field trials in swine, broilers, layers and ruminant thanks to better management of the inflammatory response. To illus- trate the combination in dairy cows, a field trial conducted in France is presented below (Table 2). The aim of this trial was to evaluate the effect of the plant extracts combination around the calving period. This is a stressful period for cows which is characterised by a sudden increase in energy re- quirements imposed by the onset of lactation or by a de- crease in voluntary dry matter intake. Homeostasis of all the energy substrates is altered during this period and it leads to an increase in intestinal inflammation and oxidative stress. Thus, the focus of this trial was on systemic inflammatory and oxidative stress markers before and after calving. The impact on fat reserves mobilisation and milk production were also studied. The trial included a total of 25 Holstein dairy cows, divided into two groups. A control group (with a corn silage based diet) with 12 animals and a test group of 13 animals which received the plant extracts combination (incorporated in concentrated feed three weeks before calving and during lactation). Blood samples were sampled on all the dairy cows


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