JULY 2022 THE RIDER /11 Research into Development of the Foal’s Gut Could Advance Treatment of Critical Cases of Diarrhea
metabolic data the team aims to learn what biomarkers denote health and which could signal a red flag as the gut becomes colonized. The team hopes to compare deviations in health that occur during critical bouts of diarrhea and use the understanding of gut mi-
of Animal Bioscience at the Ontario Agricultural College will be working under the direction of Ontario Veteri- nary College researcher, Dr. Luis Ar- royo, in a project planned to begin this summer studying mare/foal pairs to gain knowledge of how the horse’s gut environment matures. Research in ge- nomics is rapidly expanding our knowledge of digestive health but is it is not well understood why diarrhea can become life-threatening in some foals while others recover without ad- ditional symptoms. By studying both microbial and
Guelph, ON, June 22, 2022 - The foal’s gut undergoes many changes as it develops rapidly. More and more, we are learning how the colonization of a gut correlates to good health. Explor- ing the differences in foal microbiomes and how those differences may tie in with overall health has PhD Candidate, Jennifer MacNicol, very excited about the potential advancements the re- search could yield in the field of equine neonatal care. MacNicol, from the Department
ing diarrhea in healthy foals,” says Mac- Nicol. “The problem is when that does not self-limit and it becomes quite acute and quite drastic. Foals are at an increased risk, just like human babies or any other neonate, because they’re smaller and they can become dehydrated much more easily. Then you get the classic cycle where they’re dehydrated, which makes them more sick, which means they become more dehydrated.”
how rapidly a foal adapts so it can con- sume forage. “There’s often a transient self-limit-
markers could bring exciting new devel- opments in the treatment of digestive issues in foals. Equine Guelph thanks its donors that make this new innovative re- search possible. Stay tuned for future up- dates!
MacNicol - PhD Candidate, Ontario Agri- cultural College
https://www.youtube.com/watch?v=4Ma- jgpUfWww
Foal Gut Development - Jennifer Early identification through bio-
development of the GI microbiome along with the metabolome. With the metabolome, we’re going to be look- ing at the by-products of microbial ac- tivity in the gut of foals and how that begins to mimic or develop so that it’s similar to that of the mare,” explains
crobial developments in foals to move towards personalized treatments and therapeutics. “What we want to look at is the
MacNicol. “Then what we want to see in our subset (foals that develop diar- rhea) is whether that microbiome or the metabolome differ from the mare substantially compared to our healthy set.”
describe the complexities of the equine microbial environment that begins to develop at birth, how it very quickly starts to reflect that of the mare and
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